9 Mar 2024
Job Information
- Organisation/Company
Institute of Genetics and Developmental Biology of Rennes (CeDRE)- Department
UMR 6290 CNRS- Research Field
Biological sciences » Biology- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
29 Mar 2024 - 12:00 (Europe/Brussels)- Type of Contract
Temporary- Job Status
Full-time- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
Yes
Offer Description
We wish to welcome a highly motivated studies engineer in our multi-disciplinary team at the Institute of Genetics and Development of Rennes (https://igdr.univ-rennes.fr/en/ ). Research in the team focuses on the robustness of cell division through fluorescence microscopy and quantitative biophysical approaches, using the nematode model organism Caernorhabditis elegans (e.g. Bouvrais et al., 2021, EMBO report ). The current development of an automated microscope allows us to transfer our studies to cultured human cell lines without synchronization, which is a necessary condition for studying the division robustness.
Project description :
The recruited engineer will be an integral part of the on-going research project, funded by the ANR and focused on the study of the regulatory role of microtubule rigidity in cell division. Thus, he/she will participate in the work carried out so far on the nematode with experiments on human cells. The scientific objective will therefore be to reveal division defects (spindle positioning, chromosome segregation) upon impairments of proteins known to regulate the microtubule flexural rigidity. In particular, the engineer will begin this study in the context of human cancerous cells displaying deregulated expression of the proteins of interest. Therefore, the technical objective will be to generate the cell lines necessary for the study and image them using an autonomous microscope to avoid the cell synchronization step. Finally, the engineer will devote part of his/her time to experiments performed using the C. elegans nematode.
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
Skills/Qualifications
- Hold a Master's degree in molecular biology, cell biology, or closely-related disciplines.
- Strong theoretical and practical skills in cell culture techniques and generation of human cell lines with expression of fluorescently tagged proteins; Proven experience in molecular and cellular biology (cell line transfections, genetic disruptions) and fluorescence microscopy.
- Ability to work collaboratively as part of a research team ; Strong organizational and communication skills, including the ability to express him/herself in English; Performing his/her activities in a healthy and safety way ; Basic computer skills.
- Prior experience in the study of cell division or microtubules, in image and data analysis, and in the use of the nematode model will be considered very favorably without being obligatory; Interest in biophysics and interdisciplinary approaches will be considered favorably.
- Languages
- ENGLISH
- Level
- Good
- Research Field
- Biological sciences » Biology
- Years of Research Experience
- 1 - 4
Additional Information
- Website for additional job details
https://igdr.univ-rennes.fr/en/jobs-internships-opportunities-cedre-team
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- IGDR UMR6290-CNRS-Univ. Rennes - INSERM
- Country
- France
- City
- Rennes
- Postal Code
- 35043
- Street
- Campus santé de Villejean, 2 avenue du Professeur Léon Bernard
Where to apply
- Website
https://emploi.cnrs.fr/Offres/CDD/UMR6290-HELBOU-001/Default.aspx
Contact
- City
Rennes- Website
http://igdr.univ-rennes1.fr/english/equipes/recherche_equipe.php?domaine=&equipe=46&resp_equipe=- Street
2 avenue du Prof. L. Bernard, CS 34317- Postal Code
35043
[email protected]
STATUS: EXPIRED