Researcher - 3D microscopy of biologic materials by THz Atom Probe Tomography and Electron Microscopy (M/F))

21 Mar 2024
Job Information

Organisation/Company

CNRS

Department

Groupe de physique des matériaux

Research Field

Physics

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

10 Apr 2024 - 23:59 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

2 Sep 2024

Is the job funded through the EU Research Framework Programme?

HE

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The atom probe tomography (APT) is a 4D imaging technique based on the field effect evaporation of atoms from a needle-shaped nanometric sample. APT combines sub-nanometer spatial resolution with high chemical sensitivity across the entire periodic table and its isotopes. APT is a rapidly developing technique in the field of condensed matter analysis. This project is part of the European project MIMOSA Project - HORIZON-EIC-2021-PATHFINDEROPEN which aims to extend the use of the new atomic probe assisted by terahertz pulses to biological materials encapsulated in sol-gel matrices. During this project, this new instrument will be used to analyze pure sol-gel (silica) matrix and then containing antibodies, liposomes, proteins. We also plan to explore other means of sample preparation, such as cryo-milling in FIB, and sample characterization such as scanning electron microscope (SEM).
The applicant will work to the analysis of different silica matrix with and without biomaterials inside, in order to prove the capabilities of the new illumination conditions. The project involves the design and set-up of new methods for sample encapsulation and preparation. The applicant will work to the analysis of the elaborated sample using APT and electron microscopy.

- Preparation of biological samples by encapsulation in a sol-gel silica matrix
- Preparation of biological samples by cryofixation in an aqueous solution and shaping with Gallium or Xenon ions in a scanning electron microscope.
- Atomic probe analysis of samples
- Analysis of samples using electron microscopy
- Data processing
- Presentations at meetings with partners and at conferences
- Writing scientific articles for publication

The GPM (Groupe de Physique des Matériaux, UMR CNRS 6634) is divided in 5 departments: Matériaux-Vieillissement-Mécanique, Instrumentation Scientifique, Nanosciences, Systèmes Désordonnés-Polymères et Nano-Santé-Physique. 150 people (60 Reserchers, 30 Engineers et 60 PhD/PostDoct/master student) work at GPM. The GPM is located on the Campus « Sciences et Ingénierie Rouen Normandie » (Saint Etienne du Rouvray / Rouen), one of the campus of the University of Rouen Normandie (7000m2).
The recruited researcher will work as a member of the instrumentation department, within the Physics under intense fields team (fundamental aspects of field-matter interaction , 2 researchers, 1 engineer, 1 PhDoc and 3 doctoral students). This team has been working since 2005 on the development of the atomic probe assisted by ultra-short pulses.

Requirements

Research Field

Physics

Education Level

PhD or equivalent

Languages

FRENCH

Level

Basic

Research Field

Physics

Years of Research Experience

None

Additional Information
Eligibility criteria

- hold a PhD in the fields of biology or applied physics, with experimental skills in electron microscopy and correlative microscopies.
-Experience in Focused ion beam milling/or cryo-microscopy will be appreciated
-Affinity for multidisciplinary teamwork

Website for additional job details

https://emploi.cnrs.fr/Offres/CDD/UMR6634-CHRVUR-047/Default.aspx

Work Location(s)

Number of offers available

1

Company/Institute

Groupe de physique des matériaux

Country

France

City

ST ETIENNE DU ROUVRAY

Geofield

Where to apply

Website

https://emploi.cnrs.fr/Candidat/Offre/UMR6634-CHRVUR-047/Candidater.aspx

Contact

City

ST ETIENNE DU ROUVRAY

Website

http://gpm.labos.univ-rouen.fr/

STATUS: EXPIRED