Postdoctoral Researcher (M/W) in NMR Spectroscopy

11 Jan 2024
Job Information

Organisation/Company

CNRS

Department

Institut de Biologie Structurale

Research Field

Chemistry » Physical chemistry
Chemistry » Instrumental techniques

Researcher Profile

Recognised Researcher (R2)

Country

France

Application Deadline

4 Mar 2024 - 17:00 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

39

Offer Starting Date

1 Jun 2024

Is the job funded through the EU Research Framework Programme?

H2020 / ERC

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

A post-doctoral position is available in Dr. Boisbouvier's team at the Institut de Biologie Structurale (IBS) in Grenoble, France. The successful candidate will work on the development of new NMR experiments to push the biological applications of NMR beyond their current limits, and apply the new methods to the study of large molecular complexes and mmachines of medical interest. The position can be extended for up to five years and is funded by the European Research Council under the advanced grant XXL-NMR project. This position is ideal for a young post-doc who wish to progressively develop independent research and apply for a permanent research position in France

Requirements

Research Field

Chemistry » Physical chemistry

Education Level

PhD or equivalent

Skills/Qualifications

- Candidates must hold a PhD in NMR spectroscopy, structural biology, biophysics or physical chemistry (or a related field).

- Expertise or interest in the development of NMR pulse sequences for solution or solid-state NMR will be appreciated.

- Ability to conceptualize, creativity, scientific curiosity, sense of innovation.

- Good communication (written/oral) and teaching skills.

- Team spirit.

- C2 level in English (written/oral)

Specific Requirements

All research-related exchanges will be in English. To facilitate communication with IBS administrative services and integration in France, the selected candidate will have the opportunity to take French courses.

Languages

ENGLISH

Level

Excellent

Research Field

Chemistry » Physical chemistry

Additional Information
Benefits

Duration of the contract: 30 months (renewable up to 60 months)

Expected recruitment date: 01/06/2024 (can be postponed until end of 2024)

Desired post-doctoral experience: 0 to 7 years

Gross Monthly Salary: between 2905 € et 4260 € (according to experience)

Eligibility criteria

Candidates should hold a PhD in NMR spectroscopy, structural biology, biophysics or physical chemistry (or a related field), and have 0-7 years' post-doctoral experience in NMR spectroscopy. Expertise or interest in the development of NMR pulse sequences for solution or solid-state NMR will be appreciated.

Selection process

Interested candidates should send a CV with a list of publications, a covering letter and the names and e-mail addresses of two referees. These documents should be submitted by email to [email protected]

Interviews of preselected applicants will be organized in March.

Additional comments

Grenoble: Capital of the French Alps, Grenoble is a world-renowned scientific center with a strong international dimension. It's a pleasant city at the foot of three mountain ranges, offering a wide range of cultural, sporting and outdoor activities all year round. Grenoble is close to the Côte d'Azur, Italy and Switzerland, and is served by international and national airports and a high-speed rail network.

Facilities: The IBS is situated on the European Photon and Neutron campus EPN with its European partners EMBL (European Molecular Biology Laboratory), ESRF (European Synchrotron Radiation Facility) and ILL (Institut Laue-Langevin). This unique site provides access to cutting-edge equipment for analyzing biological systems at different scales of resolution. The EPN site, and the Grenoble scientific community in general, represent a veritable hub for integrated structural and dynamic biology. The IBS itself offers a lively international working environment, with state-of-the-art NMR facilities including 950, 850, 700 and 600 MHz NMR spectrometers with liquid-state cryoprobes and state-of-the-art solid-state technology, wet lab facilities dedicated to cloning, in vivo and in vitro expression and protein purification, as well as state-of-the-art imaging facilities.

Recent Relevant Publications of the Team:

• Elena-Real, Urbanek, Imbert, Morato, Fournet, Allemand, Sibille, Boisbouvier, Bernado. “Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies“. ACS Chemical Biology (2023). doi:10.1021/acschembio.3c00288
• Henot, Rioual, Favier, Macek, Crublet, Josso, Brutscher, Frech, Gans, Loison, Boisbouvier. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi: 10.1038/s41467-022-35399-8
• Törner, Kupreichyk, Gremer, Colas Debled, Fenel, Gans,, Willbold, Schoehn, Hoyer, Boisbouvier. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi: 10.1038/s41467-022-30042-y
• Gauto, Estrozi, Schwieters, Effantin, Macek, Sounier, Sivertsen, Schmidt, Kerfah, Mas, Colletier, Güntert, Favier, Schoehn, Schanda, Boisbouvier. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi: /10.1038/s41467-019-10490-9
• Mas, Guan,Crublet, Colas Debled, Moriscot, Gans, Schoehn, Macek, Schanda, Boisbouvier. “Structural Investigation of a Chaperonin in Action Reveals How Nucleotide Binding Regulates the Functional Cycle”.  Science Advances (2018). doi: 10.1126/sciadv.aau4196
• Macek, Kerfah, Boeri Erba, Crublet, Moriscot, Schoehn, Amero, Boisbouvier.  “Unraveling Self-Assembly Pathways of the 468 kDa Proteolytic Machine TET2”.  Science Advances (2017). doi: 10.1126/sciadv.1601601

Work Location(s)

Number of offers available

1

Company/Institute

CNRS/IBS

Country

France

City

GRENOBLE

Postal Code

38000

Street

71 Avenue des Martyrs

Geofield

Where to apply

E-mail

[email protected]

Contact

City

Grenoble

Website

http://www.ibs.fr

Street

71 Avenue des Martyrs

Postal Code

38000

STATUS: EXPIRED