30 Mar 2024
Job Information
- Organisation/Company
CNRS- Department
Centre de Physique Théorique- Research Field
Physics- Researcher Profile
Recognised Researcher (R2)- Country
France- Application Deadline
19 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 May 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Segmentation and tracking of oil drop deformations in lymph nodes
The aim of this project is to characterize the mechanical forces at work in lymph nodes during antigen recognition by immune cells. Our experimental collaborators (Institut Cochin, Institut Pierre-Gilles de Gennes) are using deformable oil droplets to study lymph node rheology. Most of the experiments will be carried out in organ sections, which enable the system to be physically manipulated to study the effect of tissue-scale mechanical perturbations on B cell immunological function (synapse formation and Ag acquisition). This requires the development and implementation of specific tools to monitor droplet deformations in slices of fresh lymph nodes. The mission of the post-doctoral contract is to achieve this droplet tracking, while quantifying the density and fluctuations of immune cells. From a physics point of view, we expect an increase in tissue density (induced by compression, drugs or inflammation) to modify droplet dynamics.
Development of new segmentation tools (re-training of Stardist code) and tracking tools (Trackmate) using deep learning tools. 3D cell segmentation with CellPose. Conceptualization: inference of correlations between drop deformability and displacement.
Office work at the Theoretical Physics Center.
Requirements
- Research Field
- Physics
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Physics
- Years of Research Experience
- 1 - 4
Additional Information
Eligibility criteria
Computer science (programming in Matlab, C++, Python) and theory (hydrodynamics of complex systems, statistical physics, inference methods).
- Website for additional job details
https://emploi.cnrs.fr/Offres/CDD/UMR7332-CATLEV-037/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Centre de Physique Théorique
- Country
- France
- City
- MARSEILLE 09
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR7332-CATLEV-037/Candidater.aspx
Contact
- City
MARSEILLE 09- Website
http://www.cpt.univ-mrs.fr/
STATUS: EXPIRED