11 Jan 2024
Job Information
- Organisation/Company
CNRS- Department
Institut de Biologie Structurale- Research Field
Biological sciences- Researcher Profile
Recognised Researcher (R2)- Country
France- Application Deadline
4 Mar 2024 - 17:00 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
39- Offer Starting Date
3 Jun 2024- Is the job funded through the EU Research Framework Programme?
FP7 / Ideas-ERC- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
A post-doctoral position is available in Dr. Boisbouvier's team at the Institut de Biologie Structurale (IBS) in Grenoble, France. The successful candidate will work on the development of innovative isotope labeling methods to push the biological applications of NMR beyond their current limits, and apply the new methods to the study of large, medically relevant complexes and molecular machines. The position can be extended for up to five years and is funded by the European Research Council under the advanced grant XXL-NMR project. This position is ideal for a young post-doc who wish to progressively develop independent research and apply for a permanent research position in France
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- PhD or equivalent
Skills/Qualifications
- Candidates must hold a PhD in chemistry, biochemistry or structural biology (or a related discipline) and have experience of protein expression and purification for structural biology, as well as experience or interest in solution NMR spectroscopy.
- Ability to conceptualise, creativity, scientific curiosity, sense of innovation.
- Good communication (written/oral) and teaching skills.
- Team spirit.
- C2 level English (written/oral)
Specific Requirements
All research-related exchanges will be in English. To facilitate communication with IBS administrative services and integration in France, the selected candidate will have the opportunity to take French courses.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences » BiologyChemistry » Biochemistry
Additional Information
Benefits
Duration of the contract: 30 months (renewable up to 60 months)
Expected recruitment date: 01/06/2024 (can be postponed until end of 2024)
Desired post-doctoral experience: 0 to 7 years
Gross Monthly Salary: between 2905 € et 4 260 € (according to experience)
Eligibility criteria
Candidates should hold a PhD in biology, biochemistry, biophysics, chemistry or structural biology, and have 0-7 years' post-doctoral experience in biochemistry, structural biology or biomolecular NMR. Expertise or interest in the development of isotope labeling methods will be highly appreciated.
Selection process
Interested candidates should send a CV with a list of publications, a covering letter and the names and e-mail addresses of two referees. These documents should be submitted by email to [email protected]
Interviews of preselected applicants will be organized in March.
Additional comments
Grenoble: Capital of the French Alps, Grenoble is a world-renowned scientific center with a strong international dimension. It's a pleasant city at the foot of three mountain ranges, offering a wide range of cultural, sporting and outdoor activities all year round. Grenoble is close to the Côte d'Azur, Italy and Switzerland, and is served by international and national airports and a high-speed rail network.
Facilities: The IBS is situated on the European Photon and Neutron campus EPN with its European partners EMBL (European Molecular Biology Laboratory), ESRF (European Synchrotron Radiation Facility) and ILL (Institut Laue-Langevin). This unique site provides access to cutting-edge equipment for analyzing biological systems at different scales of resolution. The EPN site, and the Grenoble scientific community in general, represent a veritable hub for integrated structural and dynamic biology. The IBS itself offers a lively international working environment, with state-of-the-art NMR facilities including 950, 850, 700 and 600 MHz NMR spectrometers with liquid-state cryoprobes and state-of-the-art solid-state technology, wet lab facilities dedicated to cloning, in vivo and in vitro expression and protein purification, as well as state-of-the-art imaging facilities.
Recent Relevant Publications of the Team:
- Elena-Real, Urbanek, Imbert, Morato, Fournet, Allemand, Sibille, Boisbouvier, Bernado. “Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies“. ACS Chemical Biology (2023). doi:10.1021/acschembio.3c00288
- Henot, Rioual, Favier, Macek, Crublet, Josso, Brutscher, Frech, Gans, Loison, Boisbouvier. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi: 10.1038/s41467-022-35399-8
- Törner, Kupreichyk, Gremer, Colas Debled, Fenel, Gans,, Willbold, Schoehn, Hoyer, Boisbouvier. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi: 10.1038/s41467-022-30042-y
- Gauto, Estrozi, Schwieters, Effantin, Macek, Sounier, Sivertsen, Schmidt, Kerfah, Mas, Colletier, Güntert, Favier, Schoehn, Schanda, Boisbouvier. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi: /10.1038/s41467-019-10490-9
- Mas, Guan, Crublet, Colas Debled, Moriscot, Gans, Schoehn, Macek, Schanda, Boisbouvier. “Structural Investigation of a Chaperonin in Action Reveals How Nucleotide Binding Regulates the Functional Cycle”. Science Advances (2018). doi: 10.1126/sciadv.aau4196
- Macek, Kerfah, Boeri Erba, Crublet, Moriscot, Schoehn, Amero, Boisbouvier. “Unraveling Self-Assembly Pathways of the 468 kDa Proteolytic Machine TET2”. Science Advances (2017). doi: 10.1126/sciadv.1601601
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- CNRS/IBS
- Country
- France
- City
- GRENOBLE
- Postal Code
- 38000
- Street
- 71 Avenue des Martyrs
- Geofield
Where to apply
[email protected]
Contact
- City
Grenoble- Website
http://www.ibs.fr- Street
71 Avenue des Martyrs- Postal Code
38027
STATUS: EXPIRED
Similar Positions
-
Postdoctoral Research Positions In Millimeter Astronomy For Noema, Institut de radioastronomie millimétrique IRAM, France, 26 days ago
IRAM is an international research organization for millimeter and submillimeter astronomy supported by the CNRS (France), the Max-Planck Gesellschaft (Germany), and the IGN (Spain). The organizati...