28 Mar 2024
Job Information
- Organisation/Company
CEA- Department
DRF/SCBM- Research Field
Chemistry » Organic chemistry- Researcher Profile
Recognised Researcher (R2)- Country
France- Application Deadline
31 May 2024 - 17:12 (Europe/Amsterdam)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Jul 2024- Is the job funded through the EU Research Framework Programme?
H2020 / ERC- Reference Number
864576- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Labeling of organic compounds with b- emitting isotopes has a remarkable impact on public health and particularly on the collection of ADME data. While radiolabeling of organic molecules has witnessed major attention, late-stage access still represents a challenge. Within the ERC project FASTLabEx , we aim to develop novel methodologies for the effective late-stage labeling of complex pharmaceutically active molecules. The project will explore new methodologies using primary carbon-labeled building blocks (CO2 , CO, etc). The use of transition metal catalysis (Pd, Ni etc) and photocatalysis will be explored.
The postdoctoral fellow will be hosted in the Laboratory of Isotope Labeling (CEA), which has an established expertise in metal catalysis, photoredox chemistry and isotope labeling. All experiments will be conducted with stable carbon-13. CEA personnel will perform experiments with carbon-14.
References:
-For recent publication from our laboratory, see: J. Am. Chem. Soc. 2024, 146, 8343−8351 , J. Am. Chem. Soc. 2023, 145, 30, 16760–16770 , Nat. Commun.2023, 14, 4451 , J. Am. Chem. Soc.2021, 143, 5659–5665 ;ACS Catal. 2021, 11, 2968−2976 ; Chem. Commun., 2020, 56, 11677-11680 ; Angew. Chem. Int. Ed. 2020, 59, 13490 –13495 ;J. Am. Chem. Soc. 2019, 141, 780-784 ;Angew. Chem. Int. Ed. 2018, 57, 9744.
Requirements
- Research Field
- Chemistry » Organic chemistry
- Education Level
- PhD or equivalent
Skills/Qualifications
the successful candidate is a skilled organic chemist, holder of a PhD in organic chemistry, with a strong scientific record and a high motivation. Good verbal and written communication skills, a flair for teamwork and synthetic methodology are required.
- Languages
- ENGLISH
- Research Field
- Chemistry » Organic chemistry
Additional Information
- Website for additional job details
https://joliot.cea.fr/drf/joliot/en/Pages/research_entities/medicines_healthcar…
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- CEA
- Country
- France
- City
- Saclay
- Postal Code
- 91191
- Geofield
Where to apply
[email protected]
Contact
- City
Saclay- Website
https://joliot.cea.fr/drf/joliot/en/Pages/research_entities/medicines_healthcare_technologies/scbm/lmc.aspx- Street
route nationnale- Postal Code
91191
STATUS: EXPIRED
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