26 Jan 2024
Job Information
- Organisation/Company
CNRS- Department
Institut de Chimie Moléculaire de l'Université de Bourgogne- Research Field
Chemistry
Biological sciences
Pharmacological sciences- Researcher Profile
Recognised Researcher (R2)- Country
France- Application Deadline
15 Feb 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Mar 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
This project aims to develop a new bioconjugation technology for the production of diagnostic and therapeutic radiopharmaceuticals. This technology uses organic molecules capable of interacting with each other rapidly and selectively, under mild conditions, compatible with the modification of biomolecules. The project is part of a 16-month prematuraturation project supported by CNRS Innovation. The aim is to mature the technology and obtain in vivo proofs of concept of its potential.
-- Organic synthesis and structural characterization of the molecular platforms for bioconjugation
- Grafting of these platforms onto targeting proteins (antibodies) by random and site-spectific (enzymatic) approaches
- Radiolabeling of bioconjugates with various radiometals: 111In, 177Lu, 68Ga
- Planning and supervision of in vivo biological studies
- Drafting of results (patent and scientific publications)
-The Institut de Chimie Moléculaire de l'Université de Bourgogne (UMR 6302) is a joint CNRS/Université de Bourgogne unit headed by Pr Jean-Cyrille Hierso (PR UB).
The person recruited will join the RITM team (Radiopharmaceuticals, Imaging, Theranostics and Multimodality) headed by Dr Victor Goncalves (MCF, Université de Bourgogne) and will work under the supervision of Dr Victor Goncalves (project leader).
The position is located in a sector covered by the Protection of Scientific and Technical Potential (PPST), and therefore requires, in accordance with regulations, that your arrival be authorized by the competent MESR authority.
Requirements
- Research Field
- Chemistry
- Education Level
- PhD or equivalent
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
- Research Field
- Pharmacological sciences
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry
- Years of Research Experience
- 1 - 4
- Research Field
- Biological sciences
- Years of Research Experience
- 1 - 4
- Research Field
- Pharmacological sciences
- Years of Research Experience
- 1 - 4
Additional Information
Eligibility criteria
- Proficiency in organic synthesis and purification techniques (flash chromatography, HPLC)
- Expertise in protein bioconjugation and bioconjugate purification and characterization (random and chemoenzymatic grafting techniques, FPLC by SEC and affinity, HPLC analysis coupled to an Orbitrap)
- Solid experience in radiolabeling (radiochemistry of metal radioisotopes, iTLC, radioHPLC)
- Good knowledge of in vivo biodistribution studies and SPECT and PET imaging.
- Website for additional job details
https://emploi.cnrs.fr/Offres/CDD/UMR6302-VICGON-001/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut de Chimie Moléculaire de l'Université de Bourgogne
- Country
- France
- City
- DIJON
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR6302-VICGON-001/Candidater.aspx
Contact
- City
DIJON- Website
http://www.u-bourgogne.fr/icmub
STATUS: EXPIRED