23 Jan 2024
Job Information
- Organisation/Company
CNRS – Inserm – Aix Marseille University- Department
Centre d'Immunologie de Marseille Luminy- Research Field
Biological sciences » Other- Researcher Profile
First Stage Researcher (R1)
Recognised Researcher (R2)
Established Researcher (R3)
Leading Researcher (R4)- Country
France- Application Deadline
23 Apr 2024 - 12:00 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The scientists will be part of a research program aiming at exploring new topics in Immuno-Oncology in collaboration with the Institut Gustave Roussy.
Context : New therapies that promote anti-tumor immunity have been developed over the last decade. Most of these immunomodulatory approaches have focused on enhancing T-cell responses, either by targeting inhibitory pathways with immune checkpoint inhibitors, or by targeting activating pathways, as with chimeric antigen receptor T cells or bispecific antibodies. Although these therapies have led to unprecedented successes, only a minority of patients with cancer benefit from these treatments, highlighting the need to identify new cells and molecules that could be exploited in the next generation of immunotherapy. Harnessing innate immunity is emerging as a promising therapeutic approach to improving the efficacy of cancer treatment and overcoming resistance to current immunotherapies targeting T cells. In particular, harnessing NK cells in cancer patients presents the dual advantage of inducing the killing of tumor cells, but also of participating in a multicellular immune response against tumor cells. Correlations have been observed between patient clinical outcome and NK cell infiltration at the tumor bed or cytotoxicity of peripheral NK cells, in several cancer indications.
We propose here to dissect the role of NK cells and type 1 innate lymphoid cells (ILC1s) in specific cancer indications with the aim of proposing innovative treatments in these diseases based on their manipulation using antibody-based drugs.
Our OFFER: We are looking for, outstanding and highly motivated post-doctoral fellows with a PhD in Immunology or Onco-immunology. Experience in cellular biology techniques, transcriptomics and flow cytometry will be highly appreciated. Scientists will be part of a rich environment with full access to state-of-the-art technologies, which should ensure the successful development of the research programs.
Requirements
- Research Field
- Biological sciences » Other
- Education Level
- PhD or equivalent
Skills/Qualifications
We are looking for, outstanding and highly motivated post-doctoral fellows with a PhD in Immunology or Onco-immunology.
Specific Requirements
Experience in cellular biology techniques, transcriptomics and flow cytometry will be highly appreciated. Scientists will be part of a rich environment with full access to state-of-the-art technologies, which should ensure the successful development of the research programs.
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- CIML
- Country
- France
- City
- Marseille
- Geofield
- Number of offers available
- 1
- Company/Institute
- Gustave Roussy
- Country
- France
- City
- Paris
- Geofield
Where to apply
[email protected]
Contact
- State/Province
France- City
Marseille- Website
http://www.ciml.univ-mrs.fr/- Street
Campus scientifique de Luminy- Postal Code
13009
[email protected]
STATUS: EXPIRED