9 Feb 2024
Job Information
- Organisation/Company
CNRS- Department
Structures biomoléculaires et cellulaires- Research Field
Chemistry » Biochemistry
Physics » Biophysics
Biological sciences » Biological engineering- Researcher Profile
Recognised Researcher (R2)- Country
France- Application Deadline
29 Feb 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 May 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The project focuses on a neurodegenerative disease characterized by specific motor neuron death caused, among others, by an aberrant translation event. The research project aims to characterize, from a functional and structural point of view, the molecular basis of this aberrant protein synthesis. Our consortium is made up of a team specialized in functional studies of translation (Franck Martin, IBMC Strasbourg) and our team, expert in structural studies of translation initiation.
The Post-doc M/F recruited will primarily use structural biology, in particular cryo-EM, to identify the ribosomal initiation and elongation complexes responsible for this aberrant translation.
Ecole Polytechnique offers a unique interdisciplinary environment, including laboratories dedicated to molecular and cellular biology, chemistry, biomechanical engineering, biophysics, optics, computer science and applied mathematics. Ecole Polytechnique is a member of the “Institut Polytechnique de Paris”. It is also part of the vibrant Saclay science cluster just south of Paris. These organizations are combining their strengths to develop the excellence of research.
A three-year post-doctoral position funded by the "Fondation pour la Recherche médicale, FRM" is available at the “Translation mechanisms” team led by Emmanuelle Schmitt and Yves Mechulam at the Structural Biology of the Cell laboratory (BIOC) at Ecole Polytechnique, https://portail.polytechnique.edu/bioc/en/recherche/translation-mechani… . The BIOC laboratory is a joint research unit of the CNRS and the Ecole Polytechnique, located on the Palaiseau campus and perfectly equipped for the project. Moreover, the laboratory has a privileged access to the CIMEX (Centre Interdisciplinaire de Microscopie Electronique de l'X) which has a Titan Themis 300kV microscope equipped with a Falcon 3 direct electron detector.
Requirements
- Research Field
- Chemistry
- Education Level
- PhD or equivalent
- Research Field
- Physics
- Education Level
- PhD or equivalent
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry » Biochemistry
- Years of Research Experience
- 1 - 4
- Research Field
- Physics » Biophysics
- Years of Research Experience
- 1 - 4
- Research Field
- Biological sciences » Biological engineering
- Years of Research Experience
- 1 - 4
Additional Information
Eligibility criteria
The candidate must hold a PhD in biology, chemistry or biophysics, and have a sound knowledge of cryo-EM and purification of macromolecular complexes.
- Website for additional job details
https://emploi.cnrs.fr/Offres/CDD/UMR7654-EMMSCH-004/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Structures biomoléculaires et cellulaires
- Country
- France
- City
- PALAISEAU
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR7654-EMMSCH-004/Candidater.aspx
Contact
- City
PALAISEAU- Website
https://portail.polytechnique.edu/bioc/fr
STATUS: EXPIRED
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