4 Apr 2024
Job Information
- Organisation/Company
CNRS- Department
Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation- Research Field
Chemistry » Physical chemistry
Chemistry » Computational chemistry- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
24 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The PhD student will interact mainly with his/her supervisors who are specialists in the development and applications of NMR methods for mixture analysis. The thesis work will be carried out in the stimulating collaborative environment of the MIMM team, involving many PhD students in NMR methodology. The applications will benefit from the collaborative environment of CEISAM (especially in synthesis).
CEISAM is the molecular chemistry laboratory of Nantes University and gathers 5 research teams recognized in theoretical, physical and analytical chemistry, and in organic synthesis. The NMR platform of the CEISAM laboratory is the largest NMR platform in the west of France. It has a large facility, including 6 high field spectrometers (400 - 700 MHz) and 3 compact NMR spectrometers. Moreover, it is part of the national research infrastructure MetaboHub. CEISAM is located in the dynamic environment of the city of Nantes, close to the Atlantic coast and South Brittany.
Context
Real-time monitoring of chemical reactions is important to understand mechanisms and to optimise reaction conditions, through kinetic measurements and the identification of intermediate species. Nuclear magnetic resonance (NMR) spectroscopy is a particularly relevant tool for reaction monitoring, as it provides quantitative information, required for kinetic measurements, and structural information, required for compound identification.
Recent developments have enabled broader access to flow NMR monitoring. In this approach, the reaction medium passes through the NMR spectrometer and can be analysed continuously. This provides real-time access to information about a reaction carried out under experimental conditions of interest, with many potential applications ranging from understanding reaction mechanisms to fully automated synthesis. However, NMR methods that are suitable for the analysis of reaction mixtures are generally not directly applicable to a flowing sample.
The MIMM team of the CEISAM laboratory develops NMR methods that are adapted to the analysis of flowing samples. In particular, we have developed ultrafast 2D NMR methods, inspired by magnetic resonance imaging concepts, that provide a full 2D spectrum in a single scan of less than a second. These methods provide a more complete description of reaction mixtures, but they remain limited by the fact that all molecules appear simultaneously in the spectrum. In order to enable the identification of new compounds, their NMR spectrum has to be obtained directly from a reaction mixture. In the case of low concentration compounds, this also requires the use of hyperpolarization methods that increase the intensity of NMR signals.
Objectives
This project aims at the development of new NMR methods for flow monitoring organic chemical reactions. Specifically, the Ph.D. student will:
• Develop NMR methods that yield all or parts of the spectrum of compounds of interest, directly from a reaction mixture
• Integrate these methods in setups for online monitoring by flow NMR, which may include a hyperpolarization step
• Apply these methods, through collaborations, to the flow monitoring of chemical reactions in batch and flow, in order to identify species with low concentrations
These aspects will benefit from the consortium's expertise in NMR spectroscopy, hyperpolarisation and reaction monitoring, as well as the corresponding equipment, which includes high-field and benchtop spectrometers.
Requirements
- Research Field
- Chemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Chemistry
- Education Level
- Master Degree or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry » Physical chemistry
- Years of Research Experience
- None
- Research Field
- Chemistry » Computational chemistry
- Years of Research Experience
- None
Additional Information
Additional comments
The candidate has a background in chemistry (preferably physical or analytical chemistry) or physics, and must be strongly interested in the development of NMR methods and their application to mixture analysis. Due to the highly collaborative nature of the project, good writing and communication skills in French and English are required. The recruited Ph.D. student will be required to train other students (Master, Ph.D.) and to present his work in international conferences.
- Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UMR6230-JEADUM-014/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation
- Country
- France
- City
- NANTES
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR6230-JEADUM-014/Candidater.aspx
Contact
- City
NANTES- Website
https://ceisam.univ-nantes.fr/
STATUS: EXPIRED