7 Apr 2024
Job Information
- Organisation/Company
CNRS- Department
Institut méditerranéen de biodiversité et d'écologie marine et continentale- Research Field
Chemistry
Biological sciences
Pharmacological sciences- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
27 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Nov 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The candidate will work in the context of the MARINDIV research project, which adopts an interdisciplinary approach to inventory the biodiversity of sessile invertebrates, dominated by Ascidians and Bryozoans, in the Bay of Marseille's marinas and ports. The first objective of this project is to characterize the metabolic profiles of collected samples, at both interspecific and intraspecific levels, examining variations in response to pollution levels and geographic origins. The second objective is to identify overproduced metabolites, which are potentially involved in detoxification and may possess antimicrobial properties.
In this context, the post-doctoral research associate will be in charge of (1) sample extraction and fractionation (2) LC-MS data acquisitions and processing trough the implementation of a standardized metabolomic workflow (from MZmine to multivariate data analyses and molecular networking), (3) participating in antibacterial assays with the prepared extracts and fractions, (4) MS data annotation combined with structure dereplication or identification of bioactive candidates
The MARINDIV project, coordinated by Charlotte Simmler (IMBE, Marseille), specialized in natural product chemistry, brings together Christophe Lejeusne (IMBE, Marseille), marine ecologist specialized in invasive species in marinas and ports, and Véronique Sinou (MCT, Marseille), a microbiologist in charge of the BAC-SCREEN platform. The post-doctoral researcher will work in close collaboration with each of them.
This interdisciplinary project associates two institutes in Marseille: the ''Institut Mediterranéen de Biodiversité et d'Ecologie'' (IMBE, UMR 7263 CNRS) and the laboratory of ''Membranes et Cibles Thérapeutiques'' (MCT, UMR_MD1, INSERM U1261) joint with the BAC-SCREEN platform.
The laboratory at IMBE is fully equipped with state-of-the-art instruments in natural product chemistry within a joint resource localized at the marine station (e.g., UHPLC-UV-HRMS with a Bruker qTOF IMPACT II, ASE automatic SPE extraction, centrifugal partition, flash and preparative chromatography). All the antimicrobial assays will be performed at the MCT laboratories with the BAC-SCREEN platform.
Requirements
- Research Field
- Chemistry
- Education Level
- PhD or equivalent
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
- Research Field
- Pharmacological sciences
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry
- Years of Research Experience
- None
- Research Field
- Biological sciences
- Years of Research Experience
- None
- Research Field
- Pharmacological sciences
- Years of Research Experience
- None
Additional Information
Eligibility criteria
Qualifications-Education: PhD in natural product chemistry with publications in scientific journals and presentations at international conferences.
Technical Skills:
Experience in MS-based metabolomics, multivariate data analyses and structure dereplication. Ability to use a varieties of open access software and molecular databases for data processing, dereplication and graphical representations. Experience in purification of natural products.
Communication skills:
Experience in writing first author-publication in English. Presentations at international conferences.
Other advantageous skills:
Keen interest in marine invertebrate biology and taxonomy.
Knowledge in microbiology and antibacterial assays.
Experience in management of sample libraries.
- Website for additional job details
https://emploi.cnrs.fr/Offres/CDD/UMR7263-KHEBOU-038/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut méditerranéen de biodiversité et d'écologie marine et continentale
- Country
- France
- City
- MARSEILLE 07
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR7263-KHEBOU-038/Candidater.aspx
Contact
- City
MARSEILLE 07
STATUS: EXPIRED