INSERM CHAIR Recruitment : Leveraging autoimmune disease understanding toward biomarkers discovery through systems immunology approaches

28 Feb 2024
Job Information

Organisation/Company

INSERM

Department

Departement des Ressources Humaines

Research Field

Medical sciences

Researcher Profile

Established Researcher (R3)
Leading Researcher (R4)

Country

France

Application Deadline

2 Apr 2024 - 17:00 (Europe/Paris)

Type of Contract

Permanent

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Oct 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Inserm chair recruitments opened to Inserm are intended for researchers with strong potential to manage and lead research teams and participate in national, European or international projects.

This recruitment, based on research and teaching projects, is aimed at researchers with a doctorate or equivalent and a first post-doctoral experience. The position is offered on a fixed-term contract (CDD) with a view to tenure in the Inserm Research Directors personnel at the end of the contract.

Strategy of the host institution :

INSERM, one of the leading biomedical research institutions in Europe and worldwide, is driven by the international dynamics of research in biology and health to delve into increasingly complex questions. This exploration requires the utilization of multidisciplinary approaches that encompass various scientific disciplines and technological expertise. Consequently, INSERM has made the recruitment of innovative profiles a key objective in its strategic plan, aiming to foster groundbreaking advancements. In line with this objective, the proposed recruitment of a junior professorship position at the i3 Laboratory perfectly aligns with INSERM's vision. The institution seeks to recruit a candidate who can harness cutting-edge approaches to advance our understanding of autoimmune diseases and push the boundaries of knowledge in immunology. In addition to contributing to these objectives, the junior professor will play a role in training young scientists and medical doctors through the Systems Immunology training program at Sorbonne Université. This will facilitate the development of novel skills in the future generation of researchers and medical professionals.

Strategy of the host laboratory :

The i3 Laboratory has been developing a translational systems immunology approach in the field of autoimmune and inflammatory diseases (AID) for over 10 years. Established collaborations with various clinical services (internal medicine, rheumatology, diabetology and the Biotherapies clinical investigation center) affiliated to AP-HP and Sorbonne Université, the multidisciplinary composition of the team (biologists, immunologists, clinicians, informaticians, and bioinformaticians) and the numerous major national and european fundings (LabEx and RHU by Investissement d’Avenir, Agence Nationale pour la Recherche ; ERC Advanced and H2020) have been pivotal to this expertise development. As such, the laboratory has generated unique massive multiparametric datasets, representing an investment of over 10 million euros for their generation, that describe the immune systems of more than 700 patients with one AID, recruited under observational or interventional clinical trials.

I3’s personel involved in systems immunology has grown from 5 members (with 2 permanent PIs) to now 15 members (including 5 permanent members (4 PIs and 1 assistant engineer). To maximize the exploitation and valorization of this investment, the i3 lab aims at recruiting a junior professor with expertise in systems immunology to introduce innovative ideas and propel the research forward.

Summary of the scientific project :

The proposed position at the i3 Laboratory will be seamlessly integrated into the research and training endeavors of the laboratory and affiliated institutions. The primary objective for the recruited researcher will be to propose innovative projects aimed at identifying biomarkers and novel therapeutic targets. For this, the recruited researcher will leverage the extensive datasets already generated by the i3 Laboratory that consist of comprehensive immunophenotyping of blood cells, full transcriptome and T-cell receptor repertoires of regulatory T-cells and effector T-cells, as well as gut microbiome data, obtained from a cohort of 700 patients with autoimmune diseases and healthy volunteers. Additionally, meticulous metadata containing accurate clinical descriptions of the patients are available.

The ideal researcher should possess a strong background in Immunology, expertise in state-of-the-art technologies, and substantial professional experience in modeling and computational biology. She/he should demonstrate a specific interest in translational research and in the intricate complexities of the immune system. By leveraging cutting-edge technologies and approaches, the appointed researcher will contribute to advancing the understanding of autoimmune diseases and ultimately enhancing patient care.

Summary of the teaching project :

The rise of holistic approaches and technological advancements necessitates interdisciplinary training for the next generation of researchers in biology, modeling, and bioinformatics. Within the i3 Laboratory, a team of members has spearheaded the establishment and coordination of the pioneering Systems Immunology training program at Sorbonne Université. This program is integrated into the third year of the Bachelor's degree (Unit of Teaching LU3SV648: Big data in Immunology - public health challenges) and the second year of the Master's degree in Molecular and Cellular Biology, specializing in Immunology through the Integrative and Systems Immunology master 2 track. The training program covers various essential aspects, including modeling, analysis of complex data, and bioinformatics. Annually, approximately 50 students from scientific, pharmaceutical, and medical backgrounds enroll in these programs. Innovative pedagogical approaches such as project-based learning and autonomous learning strategies are employed. The recruited researcher's expertise will contribute to the continued improvement and innovation of the training program, through lectures and workshops, ensuring that students receive cutting-edge knowledge and skills in Systems Immunology.

National Research Agency package : 200K€

Other package :

The i3 lab offers a well-established environment enabling the processing and analysis of the data belonging to the project. For the first period of 3 years, a post-doctoral fellow with computational background will be recruited to support the recruited researcher's in the project. Master 2 students (1 per year) will also be recruited.

Co-funding: Newly obtained grants (> 1.5M€) will provide additional funding

Remuneration : 3500-5000€ montly according to research experience.

 

Requirements

Research Field

Medical sciences

Education Level

PhD or equivalent

Additional Information
Selection process

It is expected the recruited researcher to become rapidly a group leader in the GAD team. So the candidate should demonstrate ability to supervise Ph.D students, post-doctoral fellow and technical support staff. She/he should have the capacity to obtain competitive funding to manage her/his group.

Successful candidates are chosen by a selection commission composed of six to ten members, the majority of whom are specialists in the fields of research concerned.

The commission carries out an initial examination of the applications, focused in particular on candidate experience and skills relative to the research and teaching project presented above. A shortlist of candidates is then selected for interview.
Only candidates selected by the selection committee on the basis of their applications will be invited to interview.

The interviews are followed by a deliberation during which selection commission  will discuss the quality, originality and, where appropriate, the interdisciplinarity of the research and teaching projects presented by the candidates, their motivation and their scientific and teaching supervision capacity.

The candidates selected at the end of the selection process will be offered a researcher contract, following approval from the President and CEO of Inserm.

Additional comments

Applications can be submitted online at EVA .

Deadline application: April 2, 2024

It is imperative to contact the laboratory corresponding to the Chair you have applied for in order to build the project with them.

 

Position also open to 'Bénéficiaires de l'Obligation d'Emploi' (disabled persons), as defined in article 27 of law no. 84-16 of January 11, 1984 on statutory provisions for the civil service.

Website for additional job details

https://eva3-accueil.inserm.fr/sites/eva/chaires/2024/Pages/default.aspx

Work Location(s)

Number of offers available

1

Company/Institute

Inserm UMRS 959 - I3 : Immunologie - Immunopathologie – Immunothérapie

Country

France

City

Paris

Geofield

Where to apply

Website

https://eva3-accueil.inserm.fr/sites/eva/chaires/2024/Pages/default.aspx

Contact

City

Paris

Website

http://www.inserm.fr
https://www.i3-immuno.fr/en/

Street

101 rue de Tolbiac - 75654 Paris Cedex 13

E-Mail

[email protected]
[email protected]

STATUS: EXPIRED