17 Apr 2024
Job Information
- Organisation/Company
CNRS UMR 5503- Research Field
Chemistry
Engineering » Process engineering
Physics- Researcher Profile
Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)- Country
France- Application Deadline
16 May 2024 - 22:00 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Context
From our macroscopic world, the most straightforward way to prepare small objects is to break larger ones. However, this apparent simplicity breaks down when it comes to preparing structured nano-objects, or nanocomposites. Instead, we need to precisely direct their assembly from elementary building blocks, using a bottom-up approach. During the COVID-19 pandemic, a particular organic nanocomposite came to light: the lipoplex, a hundred nm particle made up of a core of mRNA condensed by a cationic lipid and surrounded by a lipid shell. To build such a complex architecture, three assembly mechanisms are at work: the Ouzo effect, amphiphilic self-assembly and ionic complexation. To control the structure of lipoplexes, it is therefore necessary to precisely control the trajectory taken by the system in composition space. In practice, this requires a transition to a multi-stage continuous flow synthesis process. As the assembly steps are particularly rapid (ms), it is necessary to mix the various components very quickly.
Strategy
We propose to develop a rapid sequential mixing process for the robust and versatile synthesis of lipoplexes in both microfluidics and millifluidics. This tandem of fluidic scales will enable us to benefit from their respective advantages: in situ characterization and frugal parametric exploration for microfluidics, production and industrial scale-up for millifluidics. The study will be based on collaborations within the team with other components linked to the formulation-structure link and to the final purification stage, also carried out in micro/millifluidics. Radiation scattering techniques (X-rays, neutrons) will be used to characterize the objects.
Environment
The thesis will be carried out at the Toulouse Chemical Engineering center in the complex fluids & colloids team, which has around twenty members, in a multidisciplinary, varied and collaborative environment. The thesis is funded by a single-team ANR project designed to promote internal collaborations within a research team, where you will benefit from sustained and diversified supervision to train you in research. Other parts are open to applications (thesis + post-doctorate).
Conditions
A 3-year fixed-term contract will be established to carry out this thesis, ideally starting in October 2024. Net salary approx. 1600 euros.
Profil
In addition to curiosity and motivation to lead a research project, skills in micro or millifluidics and/or physical chemistry and/or radiation scattering will be particularly appreciated.
Contact
Main Supervision: Dr. Kevin Roger, Pr. Sébastien Teychené
Project leader and first contact: Dr. Kevin Roger, CNRS researcher
Funding category: Autre financement public
ANR Prosalide
PHD title: Doctorat de procédés physico-chimiques
PHD Country: France
Requirements
Specific Requirements
In addition to curiosity and motivation to lead a research project, skills in micro or millifluidics and/or physical chemistry and/or radiation scattering will be particularly appreciated.
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- CNRS UMR 5503
- Country
- France
- City
- Toulouse
- Geofield
Where to apply
- Website
https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/122952
Contact
- Website
https://lgc.cnrs.fr
STATUS: EXPIRED