Formation and maintenance of intestinal microvilli formation in C. elegans

Updated: 3 months ago
Location: Rennes, BRETAGNE
Job Type: FullTime
Deadline: 15 Mar 2024

8 Feb 2024
Job Information
Organisation/Company

IGDR
Research Field

Biological sciences » Biology
Researcher Profile

First Stage Researcher (R1)
Country

France
Application Deadline

15 Mar 2024 - 23:59 (Europe/Paris)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

36.5
Offer Starting Date

1 Jul 2024
Is the job funded through the EU Research Framework Programme?

H2020 / Marie Skłodowska-Curie Actions
Marie Curie Grant Agreement Number

101119504
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We recently started to describe the growth and dynamics of microvilli during C. elegans development (Bidaud-Meynard et al, PMID: 34704594). We will next characterize how major microvilli components contribute to microvilli growth and maintenance and how their dynamic localization and behaviour are regulated during microvilli formation. To this end, we will use loss of function approaches and analyse the role of microvilli factors using a combination of super-resolution imaging, FRAP measurements and food absorption experiments. We will investigate the role of microvilli factors that we and others have already identified, as well as new microvilli components identified by our collaborator Mike Boxem (Utrecht University, Utrecht, Netherlands) using a proteomic approach. This project will lead to the first in-depth functional characterization of microvilli growth and maintenance in a living organism during embryonic and post-embryonic development, paving the way to future studies as a model for human intestinal diseases.


Requirements
Research Field
Biological sciences
Education Level
Master Degree or equivalent

Skills/Qualifications

Candidates must hold a Master degree in Cell Biology or Developmental Biology


Specific Requirements

Candidates  must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 36 months immediately before their date of recruitment.


Languages
ENGLISH
Level
Good

Additional Information
Benefits

The Marie Skłodowska-Curie Doctoral Networks Programme offers highly competitive and attractive salary and working conditions. Each fellowship includes the following:

  • Monthly living allowance: 3,400 euro/month (€40,800/year); this amount is then adjusted through the application of a country correction coefficient to the living allowance of the country in which the researcher is recruited. The country correction coefficients are indicated in Table 2 of the MSCA Work Programme.
  • Monthly mobility allowance: 600 euro/month
  • Monthly family allowance, if applicable and depending on the family situation: 660 euro/month.

Selection process

Candidates should hold a Master degree in developmental biology or cell biology; French speaking is not required. Send a CV, a motivation letter and the name of 2 references to [email protected]  or [email protected] .

The successful applicants will be able to closely collaborate with the SurfEx teams of Mike Boxem , Lukas Kapitein  and Silvia Mihăilă  from Utrecht University ; Fernando Martin Belmonte  from CSIC ; Mikael Sellin  from Uppsala University ; Thaher Pelaseyed  from University of Gothenburg ; Daniela Pacheco  from Bac3Gel® Lda ; Martin Knight  from Queen Mary University of London ; Daniel St Johnston  from the University of Cambridge . They will also be integrated in the IGDR PhD program .


Work Location(s)
Number of offers available
1
Company/Institute
IGDR
Country
France
Postal Code
35000
Street
2 avenue du Professeur Léon Bernard
Geofield


Where to apply
E-mail

[email protected]

Contact
City

Rennes
Website

https://igdr.univ-rennes.fr/en
Street

2 avenue du Professeur Léon Bernard
Postal Code

35043

STATUS: EXPIRED