Design, synthesis and mechanisms of melanogenesis inhibitors

14 Nov 2023
Job Information

Organisation/Company

Univ. Grenoble Alpes

Department

Chimie Biologie Santé

Research Field

Chemistry » Organic chemistry

Researcher Profile

Established Researcher (R3)

Country

France

Application Deadline

10 Dec 2024 - 23:59 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Feb 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Context: Tyrosinase is the key enzyme involved in the biosynthesis of melanin, pigment found in the skin
and eyes that are the cause of various diseases. For discovering efficient tyrosinase inhibitors, our strategy
is to target the tyrosinase dicopper active site which plays a central role in tyrosinase activity.
Methodology: (i) The design of these new inhibitors will be inspired by the integration of knowledge of the
tyrosinase enzyme or biomimetic model structures and by the use of the fundamental recognition properties
of inorganic chemistry. Substrate mimics or known inhibitors combined with groups able to bind selectively
to the active site of the dicopper should yield safe and potent compounds according to a strategy validated
by our recent results.
(ii) Although the project requires an organic synthesis background, the question of how selected inhibitors
(or potential inhibitors) bind/interact with the active site of the enzyme using computational approaches is
also part of the project aimed at understanding inhibition mechanisms and streamlining the design of
improved inhibitors.
(iii) In addition, the candidate will interact with a well-established network of external partners to evaluate
the activity of the synthesized molecules.

Requirements

Research Field

Chemistry » Organic chemistry

Education Level

PhD or equivalent

Skills/Qualifications

The candidate should be highly motivated, to work in a multidisciplinary project and to
interact with external partners. The project requires a solid experience in organic syntheses, as well as an
interest for bioinorganic chemistry. A background in molecular modeling is an advantage.

Specific Requirements

Application: To apply, please send a CV (max. one page), PhD degree less than 3 years ago, covering letter
and details for potential referees to the contacts.

Contacts/Location
Du MOULINET D’HARDEMARE Amaury/ BELLE Catherine
DCM, Equipe CIRe, 301 rue de la Chimie, Bat C, CS 40700, 38058 GRENOBLE cedex 9, France,
Mail to: [email protected] & catherine.belle@univ-grenoble alpes.fr

Languages

ENGLISH

Level

Good

Languages

FRENCH

Research Field

Chemistry » Organic chemistry

Years of Research Experience

4 - 10

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

UGA/DCM

Country

France

City

Grenoble

Street

301 rue de la chimie

Geofield

Where to apply

E-mail

[email protected]

Contact

City

Saint-Martin-d'Hères

Website

https://dcm.univ-grenoble-alpes.fr/research/cire-team

Street

621 avenue Centrale

Postal Code

38400

STATUS: EXPIRED