Deciphering the complex energy landscape of the human chaperone HSP90 at atomic resolution using advanced NMR methods
18 Mar 2024
Job Information
- Organisation/Company
CEA- Department
Structural Biology Institute- Research Field
Chemistry » Physical chemistry
Physics » Biophysics
Chemistry » Biochemistry- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
1 May 2024 - 23:59 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
39- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
A PhD position is available in the NMR of Large Assembies group led by Dr. Boisbouvier, at the Structural Biology Institute (IBS) in Grenoble, France. The successful candidate will use advanced isotope labeling and NMR methods at variable temperature and pressure to identify and characterize the structure and dynamics of rare functional states of the human chaperone HSP90. The position is funded by the French Atomic Energy and Alternative Energies Commission (CEA). The successful candidate will work under the supervision of Dr. Boisbouvier (IBS, Grenoble) and in close collaboration with Dr. E. Lescop (ICSN, Gif sur Yvette).
Requirements
- Research Field
- Chemistry » Physical chemistry
- Education Level
- Master Degree or equivalent
Skills/Qualifications
Candidates should hold or prepare an Engineer diploma or a Master degree in physical chemistry, structural biology, biophysics or a related field.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Chemistry » Physical chemistry
- Years of Research Experience
- None
Additional Information
Benefits
Gross salary: €2,561/month, health insurance, partial reimbursement of local transport expenses, 50 days vacation a year.
Duration : 3 years.
Eligibility criteria
Candidates should hold or prepare an Engineer diploma or a Master degree in physical chemistry, structural biology, biophysics or a related field.
Selection process
Interested candidates should send a CV, a covering letter and the names and e-mail addresses of two referees. These documents should be sent by e-mail to [email protected] and [email protected] by May 1st 2024.
Additional comments
Relevant Publications of the Teams:
- Henot et al. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi:10.1038/s41467-022-35399-8
- Pozza et al. “Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure”. Nature Communications (2022). doi: 10.1038/s41467-022-29410-5
- Törner et al. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi:10.1038/s41467-022-30042-y
- Gauto et al. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi:10.1038/s41467-019-10490-9
- Mas et al. “Structural Investigation of a Chaperonin in Action RevealsHow Nucleotide Binding Regulates the Functional Cycle“. Science Advances (2018). doi: 10.1126/sciadv.aau4196.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- CEA/Structural Biology Institute
- Country
- France
- City
- GRENOBLE
- Postal Code
- 38000
- Street
- 71 Avenue des Martyrs
- Geofield
Where to apply
[email protected]
Contact
- City
Grenoble- Website
http://www.ibs.fr- Street
41 rue Jules Horowitz- Postal Code
38027
[email protected]
STATUS: EXPIRED
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