Analysis of turn-rich bioactive peptide properties through an approach combining solution and solid-state NMR and theoretical calculations
1 May 2024
Job Information
- Organisation/Company
UMR 6014 CNRS- Research Field
Chemistry
Chemistry » Biochemistry- Researcher Profile
Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)- Country
France- Application Deadline
25 May 2024 - 22:00 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Bioactive peptides have emerged as a promising class of drugs in the field of pharmacology, due to their specificity and their capacity to selectively target distinct biological processes. Their use as therapeutic agents has become widespread, with various administration routes (dry or wet forms). An important question is how the peptide structure may be affected by the nature of the formulation.
The main objective of this project is to evaluate the impact of the physical state of bioactive peptides, especially those rich in turns in drug preformulation stages. To this end, we plan to develop an approach combining liquid and solid-state NMR, as well as theoretical calculations. We will first investigate the complementarity of liquid and solid-state NMR in beta-turn characterization using model peptides. Then we will apply the developed methodologies to bioactive peptides of interest.
Funding category: Contrat doctoral
PHD title: Doctorat de Chimie
PHD Country: France
Requirements
Specific Requirements
The applicant should have a Master Degree with a speciality in Analytical Chemistry, Physical Chemistry or Structural Biology. He/She must also have taken courses on NMR spectroscopy. Crystallisation, peptide/protein NMR or molecular modeling knowledge would be an asset. Fluency in English (both oral and written) is mandatory.
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- UMR 6014 CNRS
- Country
- France
- City
- MONT-SAINT-AIGNAN
- Geofield
Where to apply
- Website
https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/123498
Contact
- Website
https://www.lab-cobra.fr/
STATUS: EXPIRED