A new generation of printed biosensors for highly sensitive and quantitative biomarkers monitoring based on transistors and nanozymes

8 Apr 2024
Job Information

Organisation/Company

Université Paris Cité, ITODYS Laboratory

Department

Chemistry, ITODYS Laboratory

Research Field

Chemistry » Molecular chemistry
Chemistry » Physical chemistry

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

30 Apr 2024 - 23:59 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Oct 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

PhD position in Paris, Laboratory ITODYS, BiOSS team (Bioelectronics and Smart Surfaces).

Open in Oct. 2024.

 

Monitoring biomarkers such as virus, biomolecules or hormones produced by the endocrine system holds paramount significance. Hormones, along with other biomarkers, serve as pivotal indicators of the body's physiological processes and functions. Even though optical transduction is nowadays the main detection modes used in biosensors, their replacement by electrochemical transduction would offer noteworthy advantages such as the possibility to operate in nontransparent or colored reaction mixtures and to directly produce an electronic signal that can be automatically treated and sent to the user. The PhD project aims to develop a generic printed biosensor for low cost, highly sensitive and quantitative hormones monitoring.  To this end, a highly selective enzyme-linked aptamer assay (ELAA) will be combined to an Organic ElectroChemical Transistor (OECT) transducer functionalized with a new generation of hybrid electrocatalyst. Organic ElectroChemical Transistor (OECT) devices are promising according to their ability to amplify interfacial events occurring onto the channel or gate electrodes.

The objective of this PhD project is to modify the OECT gate with an H2 O2  ultrasensitive nanostructured interface, a key element of the final printed biosensor.

Highly selective nanocatalysts (nanozymes) for H2 O2  oxidation encompassing a metal core and H2 O2 -responsive supramolecular shell will be synthesized and characterized by several physico-chemical techniques available in the laboratory (NMR, GC-MS, IR, electrochemistry, STM, AFM, XPS, SEM-EDX). The formulation and the printing of H2 O2 -sensitive nanozymes inks onto the gate electrodes will be optimized in order to obtain a highly active nanostructured interface. Finally, the fabrication of coplanar OECT biosensor on flexible substrate encompassing the smart H2 O2  nanozyme will be performed by printing techniques within the PrintUp platform (https://printupinstitute.fr/en/research-development/ ) led by the BiOSS team. The performance of the modified OECT will be assessed as a function of both the architecture and the nanocatalysis triggered by H2 O2 . 

This project will integrate supramolecular and molecular synthesis, electrochemistry, surface functionalization and printing fabrication techniques (namely inkjet-printing).

 

Location/supervision: The thesis will be conducted within the ITODYS Laboratory in Université Paris Cité. The PhD project will be co-supervised by Prof Benoît Piro and Dr Samia Zrig

Requirements

Research Field

Chemistry » Molecular chemistry

Education Level

Master Degree or equivalent

Research Field

Chemistry » Physical chemistry

Education Level

Master Degree or equivalent

Skills/Qualifications

Profile: The PhD candidate with a Master’s degree in Chemistry should be a highly motivated student with a solid background in organic synthesis and supramolecular chemistry. The candidate should also have knowledge in molecular electrochemistry and/or spectroscopy.

Team-working abilities, organization and good communication and writing in English are required

Specific Requirements

How to apply? The applicant will send an email to Dr Samia Zrig ([email protected] ) and attach a CV, a short (max 2 pages) research summary about previous experiences/internships (if any), a motivation letter and the contact of 2 references he/she worked with.

Languages

ENGLISH

Level

Excellent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Université Paris Cité, ITODYS Laboratory

Country

France

City

Paris

Postal Code

75013

Street

15 rue Jean Antoine de Baïf

Geofield

Where to apply

E-mail

[email protected]

Contact

Website

https://u-paris.fr
https://www.itodys.univ-paris-diderot.fr/fr/

E-Mail

[email protected]
[email protected]

STATUS: EXPIRED