Senior Researcher (Co-PI)

The University of Helsinki (https://www.helsinki.fi/en ) is among the leading multidisciplinary research universities in the world. In addition to its 11 faculties, the University includes several independent institutes, some of which are jointly operated with other universities. Some 35,000 students are currently pursuing an undergraduate or a postgraduate degree at the University of Helsinki.

The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The Faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare.

The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.

Laboratory of Professor Jussi Taipale at the Medical Systems Biology group (https://www2.helsinki.fi/en/researchgroups/medical-systems-biology ) at the Applied Tumour Genetic Program at University of Helsinki, Faculty of Medicine invites applications for the position of

SENIOR RESEARCHER (Co-PI) IN TAIPALE GROUP

Our research group is part of the Academy of Finland's Centre of Excellence in Tumour Genetics Research. The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer.

CANDIDATE REQUIREMENTS

Position includes both scientific and administrative tasks, with the latter consisting of personnel (such as supervision of lab members, recruitment) and financial responsibilities (such as handling grant applications, reporting to financing bodies and planning and executing larger purchases). Scientific part constitutes ca. 75% of the tasks and requires a strong background in any of the following fields: molecular biology, genetics, medicine, biochemistry or computer science. Applicants should be interested in working in an interdisciplinary environment as the laboratory combines experimental and in silico analyses.

For additional information about the position, please contact Dr. Daniela Ungureanu: daniela.ungureanu (at) helsinki.fi.

WHAT WE OFFER?

The position is available from September 2022 onwards, and can be started upon agreement. A six-month trial period will be applied. Salary will be commensurate with qualifications and experience based on the University guidelines. It is a 3-year fixed-term position, with a possibility of extension.

HOW TO APPLY?

Please submit your application as a single PDF file containing your CV, publication list including impact factors and two letters of reference through the University of Helsinki’s electronic recruitment system at https://www2.helsinki.fi/en/open-positions/senior-researcher-co-pi-in-ta... > Apply for the position.

The deadline for applications is 13 March 2022.

SELECTED PUBLICATIONS FROM TAIPALE LAB

Sahu et al. Sequence determinants of human gene regulatory elements. Nature Genetics, 2022, in press.
Sahu et al. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021, Sept, 5533-5547.
Zhu et al. The interaction landscape between transcription factors and the nucleosome. Nature. 2018, Oct, 76-81.
Yin et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 2017, May 5;356(6337).
Turunen et al. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Rep 7, 654–60.
Yan et al. (2013) Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell 154, 801-13.