4 bioinformatics / quantitative cell biology scientists for biomedical research

The Institute of Biomedicine at the University of Eastern Finland is inviting applications for 4 positions to be appointed from September 1st, 2022 to December 31st, 2025: 2 bioinformaticians to work on multimodal data integration tools:

1) Project / Postdoctoral bioinformatics researcher to develop “Multimodal Biomedical Data Analysis” solutions at the Bioinformatics Centre core facility:

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&... rel="noopener noreferrer" target="_blank">">https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&...

2) Project bioinformatician to develop and implement a bioinformatics data processing pipelines for genomic, genetic, other multi-omics, imaging and clinical data related to neurosciences and neurodegenerative diseases:

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&... rel="noopener noreferrer" target="_blank">">https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&...

and 2 cell/molecular biologists or quantitative scientists (physicists/applied mathematicians) to decipher design principles of the molecular networks at the systems level using single cell -omics, quantitative bio-imaging technologies, computational analysis and modeling:

3) postdoctoral fellow to decipher the quantitative determinants underlying transitions between cell states:

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&... rel="noopener noreferrer" target="_blank">">https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&...

4) PhD candidate to scrutinize the coordination between cell growth and division at the quantitative level in order to unlock the secrets of cell size control across organisms:

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&... rel="noopener noreferrer" target="_blank">">https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&...

Description of the positions:

1) The Bioinformatics Centre (https://bioinformatics.uef.fi/ rel="noopener noreferrer" target="_blank">">https://bioinformatics.uef.fi ) is seeking for a highly motivated and talented Project Researcher / Postdoctoral research associate interested in a career path as core facility expert to develop the “Multimodal Biomedical Data Analysis” solutions, that is a central area recognized by the UEF Research Communities in cancer, metabolic, cardiovascular and neurodegenerative disease. Current services include state-of-the-art genomics and genetics data analysis workflows. Your role will be to develop and lead multimodal data analysis services in tight connection with biomedical and data analysis experts from the research communities. Modern biomedical research expands from disease genetics to characterization of the disease phenotype at multimodal (omics, imaging) levels. The project will offer a unique opportunity to develop expertise in combining genomics, metabolomics, proteomics, clinical and imaging data from the local cohorts as well as other resources like FinnGen. Your main responsibilities will be to develop and implement data integrative pipelines and multimodal analysis methods in R, Python and/or shell languages.

2) The Genetics of Gene Regulation in Disease research group (https://uefconnect.uef.fi/en/group/genetics-of-gene-regulation-in-disease/ rel="noopener noreferrer" target="_blank">">https://uefconnect.uef.fi/en/group/genetics-of-gene-regulation-in-diseas... ) and the Kuopio NPH and Early AD research group at the Institute of the Clinical Medicine and the Neurosurgery of Kuopio University Hospital NeuroCenter (https://sites.uef.fi/crc/nph-and-early-ad-group/ rel="noopener noreferrer" target="_blank">">https://sites.uef.fi/crc/nph-and-early-ad-group/ ) are seeking a highly motivated and talented bioinformatician to join the project “Genomics of iNPH and neurodegeneration”. This ambitious neuroscience project aims to decipher the genomics and genetics of idiopathic normal pressure hydrocephalus (iNPH) and identify candidate disease driver genes at the single cell level in iNPH and its pathologies related to neurodegeneration, especially Alzheimer’s disease. Due to the early AD pathology present in a subpopulation of iNPH, the brains of the iNPH patients offer a unique window to evaluate how early AD pathology impairs neuronal network functions in living human brain tissue. Your main responsibilities will be to develop and implement a bioinformatics data processing and analysis pipelines mainly in R, Python and/or shell languages for the integrative analysis of genomic, genetic, and other multi-omics data types together with patient-related clinical data (multimodal data integration).

3) The Heinäniemi (https://uefconnect.uef.fi/en/group/systems-genomics-heinaniemi-lab/ rel="noopener noreferrer" target="_blank">">https://uefconnect.uef.fi/en/group/systems-genomics-heinaniemi-lab/ ) and Tollis (https://uefconnect.uef.fi/en/group/quantitative-cell-biology/ rel="noopener noreferrer" target="_blank">">https://uefconnect.uef.fi/en/group/quantitative-cell-biology/ ) research groups are seeking for a committed and enthusiastic Postdoc / Project Researcher to decipher the quantitative determinants of cellular fate choices at the G1/S transition of the cell cycle. This basic science project also has a strong translational aspect in context of aberrant gene regulation and “bad” cellular choices that lead to acute lymphoblastic leukemia (ALL). We use a range of state-of-the-art single cell genomics technologies to capture the repertoire of cell states in tissues, and strip down cellular pathways regulating cell fate decisions to core, tractable subnetworks structures. Synergistically, we use avant-garde quantitative imaging techniques to measure critical cellular parameters in live cells, in order to understand how structures are dynamically modulated to gather, and process environmental information. At the interface between the two groups, you will measure the abundance, localization, dynamics and interactions of key cell cycle drivers in order to formalize quantitative determinants of cell fate choices, and discover molecular regulatory circuits and their functioning at the systems level, both in cell models and pre-clinical human studies.

4) The Quantitative Cell Biology (Tollis) group is also recruiting an Early-Stage Researcher (Ph.D. candidate) to discover the quantitative determinants that underlie cell size control at the G1/S transition of the cell cycle across organisms. This fundamental biology question has been open for 150 years, and has implications in context of aberrant size regulation and cell proliferation in cancer. You will use biochemical, cell / molecular biological experiments and quantitative imaging techniques to measure quantitative parameters of the core genetic network that controls commitment to cell division and its interplay with cellular growth, and to reveal how they are modulated by the cellular environment to adjust cell size to growth conditions. Together with the team you will develop computational models and data analysis tools to integrate those diverse datasets into predictive models of size control.

Research environment:

The University of Eastern Finland is one of the most multidisciplinary universities in Finland. We are home to 16,000 students and 2,750 staff members. Our research is ranked among the best in the world in several fields. We generate research-based knowledge and make it openly accessible for the benefit of all. UEF stands for action with impact that is relevant today and tomorrow. To learn more about our university please visit our website at 

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Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognized research activities are closely linked to the strategic research areas of the University. There are approximately 3,100 degree students and about 580 PhD students in the Faculty. The faculty has 795 staff members. http://www.uef.fi/en/ttdk/etusivu rel="noopener noreferrer" target="_blank">">http://www.uef.fi/en/ttdk/etusivu . You will have an opportunity to work in an interesting and diverse role as part of our international, creative, participatory, and inclusive academic community.

You will join our fast-growing local network of quantitative scientists and bioinformaticians and be able to use the high-capacity computational and Quantitative Imaging infrastructures of the local Bioinformatics and Cellular Imaging centers,