Post doc position in the field of multi-organ disease modelling in mice

Updated: 4 months ago
Deadline: 09 Mar 2020

The University of Oulu (https://www.oulu.fi/university/) in Northern Finland, with approximately 15 000 students and 3000 employees, is an international, multidisciplinary research university with a rich pool of creative and intellectual talent. The strengths of the University are broad, multidisciplinary research interests, a modern research and study environment, and wide cooperation with international research and educational institutes.

There is an open position for a postdoctoral scientist in the research project of associate professor Reetta Hinttala (http://www.oulu.fi/university/researcher/reetta-hinttala ). The position is located in the PEDEGO research unit, Faculty of Medicine; and in the Transgenic core facility, Biocenter Oulu; University of Oulu.

Description of the position

You will be responsible for generation and analysis of new mouse models for severe neurological multiorgan syndromes of childhood. Our earlier discovery of a novel severe neurodegenerative disease in childhood with fibrosis, and cerebral angiomatosis (FINCA disease) has highlighted the importance of a new disease causing gene, NHLRC2, in the tissue homeostasis of multiple organs. In this project, the physiological role of NHLRC2 is characterized in our recently created FINCA knock-in mouse model. In addition, novel knock-in mouse lines will be created and analysed for syndromes of Finnish Disease Heritage.

Required qualifications and assessment

We expect you to havea PhD degree in molecular biology, biochemistry, animal science, developmental biology, immunology or a related field. Previous experience with CRISPR-Cas9 editing, disease modelling including phenotyping of mouse models, organ and tissue pathology or other supporting techniques will be considered as assets. We are looking for a highly motivated scientist who has good communication, collaboration and teamwork skills. Fluency in both written and spoken English are required. Demonstrated experience in writing scientific publications, and in acquiring supplementary funding will be taken as merits.

We offer

multidisciplinary environment for research. Biocenter Oulu (established in 1986) is one of the four strategic focus institutes at the University of Oulu. Biocenter Oulu supports high-quality research and promotes interdisciplinary networking of research groups as well as co-operation with national and international partners. Biocenter Oulu (BCO) research infrastructure core facilities are part of the University of Oulu Infrastructure Unit and they belong to the national distributed Biocenter Finland network. BCO transgenic core facility is the Finnish node of INFRAFRONTIER. (https://www.oulu.fi/biocenter/ ) (www.infrafrontier.eu ) PEDEGO conducts extensive basic and clinical research in its fields, which are Dermatology, Otorhinolaryngology, Pediatric Surgery, Pediatric Neurology, Child Psychiatry, Pediatrics, Clinical Genetics, Ophthalmology and Obstetrics and Gynecology. The high level of the unit’s research is reflected in the substantial amount of competitive research funding received. In addition to research, PEDEGO is responsible for basic medical education as well as clinical and scientific postgraduate education.

The research will be carried out in close collaboration with basic scientists and clinicians from Finnish and European universities.

Salary

The salary will be based on level 5  of the demand level chart for university-level teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component). The duration of the position is two years. The starting date is the 1st of May, 2020, or as soon as possible thereafter.A six-month trial period will be effective in the beginning of a two-year contract.  

Application

The application must contain the following documents:

1) Motivation letter outlining your research interests, scientific writing skills and relevant work experience

2) Curriculum vitae

3) Bibliography

4) Contact information for 2-3 references

Applications, together with all relevant attachments, must be submitted using the electronic application form by Monday, March 9, 2020. Applications sent by email will not be considered.

For further information regarding this position:

Associate professor Reetta Hinttala, group leader, University of Oulu, Faculty of Medicine, Biocenter Oulu, email: reetta.hinttala(at)oulu.fi

Tiina Hurskainen, HR Manager, email: tiina.hurskainen(at)oulu.fi


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