Proteomics Core Facility Manager

The Proteomics Core Facility at the Department of Biotechnology and Biomedicine (DTU Proteomics Core) has an opening for a position as operational manager. The position will be available from November 1st , 2021.

The DTU Proteomics Core is a very well-equipped academic proteomics core facility and supports academic and industrial scientists both at DTU and beyond in their research by providing a wide range of proteomics services using various platforms for protein and peptide separation, state-of-the-art mass spectrometers for LC-MS analysis and specialized bioinformatics tools for data analysis. The facility provides service and engages in collaborations within advanced labeled and label-free quantitative proteomics, targeted proteomics and Data-Independent Acquisition workflows. We have a long-standing record and focus on high-sensitivity analysis of very limited sample amounts, all the way down to single cells. From November 2021, the scientific supervisors of the facility will be Associate Professor Erwin Schoof and Professor Ulrich auf dem Keller, supported by a steering committee of key proteomics researchers at DTU.

The DTU Proteomics Core is located at the DTU Lyngby campus in a recently constructed building housing ultra-modern, purpose-built laboratories for protein research. Currently, the facility hosts five ThermoFisher Orbitrap mass-spectrometers (two Eclipse Tribrids, one Exploris480 and two Q Exactive Classics), with FAIMSPro capability on the latest-generation instruments. For advanced chromatography methods, we have a U-3000 offline high pH fractionation system, and utilize online U-3000, Easy nLC1200 and EvoSep One platforms to support all modern proteomics approaches.

The job
The position implies daily supervision of all aspects of the core facility functioning in close collaboration with the existing lab manager. The core manager is responsible for managing staff, maintaining equipment, developing and following standard operating procedures, developing and maintaining customer connections and running the projects. Budgeting and invoicing will be conducted together with the lab manager.

The future of the DTU Proteomics Core will be significantly influenced by the professional contribution of the applicant. You will be involved in important biotechnological, biomedical and chemical projects, and be closely involved with on-going efforts to optimize ultra-low input workflows such as LCM tissue and single cell proteomics workflows. This includes high-profile collaborations with leading manufacturers in mass spectrometry instrument technology, chromatography and sample preparation. You will also contribute to training activities, including giving technical introductions to the customers, as well as supervision of visiting students and postdocs. Own research in technological developments in proteomics will be strongly encouraged. Applying for own research grants is not obligatory but highly recommended.

Qualifications
Candidates should have a PhD or equivalent, with documented experience in day-to-day handling of modern mass spectrometry instrumentation of at least 2-3 years.

For this position, a service-oriented personality as well as a high social competence are essential. The ideal candidate has a strong background in mass spectrometry and proteomics, as well as excellent understanding of the technology involved, including liquid chromatography, high-resolution mass spectrometry, bioinformatics and related software. A strong grasp on approaches such as DDA, DIA, PRM, SureQuant and TOMAHTO is essential, including downstream analysis using e.g. Proteome Discoverer, Spectronaut, Spectromine, MaxQuant or Skyline.

The applicant should possess at least a core understanding of biochemistry, molecular biology, and biotechnology and be familiar with typical proteomics tasks.

Organizational, managerial, leadership and interpersonal skills are of particular importance. The ideal applicant must have strong motivation and excellent work ethics. The ability to effectively interact with the research and technical staff within the group as well as external researchers in a team-oriented manner is a must.

Advanced knowledge of English is essential as this is the working language.

We offer
We offer an interesting and challenging job in an international atmosphere with the focus on research, teaching, innovation and scientific advice for the benefit of the surrounding community. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position. In the area of technical and natural sciences, DTU is one of the leading research and education institutions in Europe.

Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union.

The position is initially available for 3 years.

Application procedure
Please submit your online application no later than 31 October 2021 (Danish time). However, applications received will be reviewed on a rolling basis to ensure a timely process.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Diploma (MSc/PhD)
• List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.