Postdoctoral research position at Copenhagen Center for Glycomics

Updated: 29 days ago
Deadline: 31 Dec 2021

Postdoctoral research position at Copenhagen Center for Glycomics (CCG)

Department of Cellular and Molecular Medicine (ICMM)

Faculty of Health and Medical Sciences

University of Copenhagen

We are looking for a one or more highly motivated and skilled researcher(s) with experience in studies of cell-surface receptors/adhesion molecules, glyco-proteomics, affinity-proteomics (interactomics), and/or glycobiology.

The successful candidate will be employed as postdoctoral researcher at the Department of Cellular and Molecular Medicine at the Faculty of Health and Medical Sciences, University of Copenhagen. The initial appointment will be for 2 years starting as soon as possible after March 2022 and, provided adequate performance, can be renewed for an additional 2 years.

ABOUT CCG
Copenhagen Center for Glycomics (CCG) is a Danish National Research Center devoted to the study of diseases caused by defects in the biosynthesis and structure of complex carbohydrates. Currently, CCG comprises seven research groups and hosts about 10 postdocs and 10 PhD students in addition to Master students and guest researchers. CCG strives be a leader in glycosciences in pioneering transformation of the field towards wider integration into main stream cell biology by developing experimental strategies, informatics approaches, and sustainable resources amenable not only to experts. We aim to facilitate discovery of diseases caused by altered glycosylation, develop new diagnostic and therapeutic tools, and identify new ways to design and produce improved glycoprotein drugs. CCG is a cutting-edge interdisciplinary research and training Center located on the 10th floor of the new Mærsk Tower science building within the Department of Cellular and Molecular Medicine (ICMM). CCG has state-of-the-art facilities for mass spectrometry, flow cytometry, cell engineering, and glycan arrays, and the senior leaders hold diverse expertise in all areas of glycosciences. Our core valuables include glycoproteome data and bioinformatics tools, validated gene editing tools, glycoengineered cell libraries, and design matrices for recombinant production of glycotherapeutics. CCG hosts an international seminar series, PhD courses in glycobiology and gene editing, and participates in ICMMs education program. More information can be found at www.glycomics.ku.dk

RESEARCH TOPICS AND TASKS
The research program is focused on the regulations and functions of O-linked mannose (O-Man) glycosylations. We have discovered new biosynthetic pathways based on O-Man on major classes of mammalian plasma membrane proteins, including the cadherin superfamily of adhesion molecules and semaphoring-plexin receptors. Deficiencies and mutations in the biosynthetic enzymes responsible for the novel types O-Man in mammals is known to cause multiple forms of developmental disorders with neurological phenotypes (e.g. severe brain malformations) indicating that this unique form of post-translational modification (PTM) serves critical but unexplored roles in human health and disease.   

The successful candidate will develop and apply new analytical methodology to dissect structure-function relationships for the newly discovered O-Man glycosylation pathways, establish human cell lines with CRISPR/Cas9 knock-out/knock-in of relevant genes and further develop and apply cutting-edge workflows for quantitative O-Man glycoproteomics. Specific research projects include exploration of O-Man functions on cadherins, protocadherins, semaphoring-plexins, c-MET and/or RON receptors in development and cancer.  

CCG houses a high throughput CRISPR/Cas9 gene targeting platform and has developed a comprehensive validated CRISPR library (GlycoCRISPR) to dissect the human glycome. We have used this to develop a large library of isogenic human cells with different glycosylation capacities, which constitutes a cell-based glycan array (GlycoDisplay). This resource enables display and dissection of interactions with glycans as well as production of glycoproteins with custom designed glycans.

The successful candidate will further develop the GlycoCRISPR and the GlycoDisplay programs and engage in wide collaborative efforts for use of these resources in discovery of biological functions of the O-Man glycome.

Applicants for this position should be highly organized and motivated to take on project leadership responsibilities. The candidate is expected to devise strategies for management and exploration of -omics datasets and develop collaborative and interdisciplinary networks, including responsibilities of:

  • research, including publication/academic dissemination duties
  • research-based teaching
  • sharing knowledge with society

YOUR PROFILE

  • You have a PhD in Biochemistry / Glycobiology or related areas      
  • You possess research experience and publication records in the cell biology field with emphasis on one or more of the topics mentioned above
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Assessment of applicants will primarily consider their level of documented, internationally competitive research. Applications from candidates with prior post-doctoral experience are encouraged and will be prioritized. Teaching qualifications are not mandatory but documented teaching qualifications and teaching experience will be considered. Candidates with documented experience in studies of cell-surface receptors/adhesion molecules, glyco-proteomics, affinity-proteomics (interactomics), glycobiology, and/or gene editing, will receive advantaged consideration.   

Place of employment
The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMMoffers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programmes, three high profile Research Centers as well as several international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. More information can be found at www.icmm.ku.dk

Terms of employment
The employment as postdoctoral fellow is a full-time and fixed-term position for 2 years starting February 2022 or after agreement. Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations).

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

Questions
For further information please contact the Center Administrator, Mel Robbins, mrobbins@sund.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page)

2. CV incl. education, work/research experience, language skills and other skills relevant for the position

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do

4. List of publications

5. Teaching portfolio if applicable

Application deadline:  31 December 2021, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.


Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


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