Postdoctoral positions Protein signaling in genome maintenance

Two fully funded postdoctoral positions with a duration of two years are available in the Mailand Group at Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk ), University of Copenhagen, Denmark. Starting date 15 September 2022 or after agreement.

Mailand Group at CPR
CPR promotes basic and applied discovery research on human proteins of medical relevance. The Center is a strong hub for cutting-edge research on protein signaling and human disease, comprising excellence and state-of-the-art facilities within multiple areas of protein science. Research in the Mailand Group aims to understand how signaling processes driven by ubiquitin, SUMO and other post-translational protein modifications function in genome maintenance processes that underpin cell fitness. We combine system-wide CRISPR screening- and proteomics-based approaches with a broad panel of targeted methodologies within cell biology, biochemistry and advanced microscopy to chart cellular signaling processes and characterize their functional significance and mechanistic underpinnings. We offer a vibrant, ambitious and highly international research environment, as well as access to cutting-edge facilities within protein science, including state-of-the-art proteomics and microscopy platforms.

For more information please visit: https://www.cpr.ku.dk/research/proteinsignaling/mailand/ .

Job description and project
Research in our lab revealed important roles of ubiquitin- and SUMO-mediated signaling in preventing genome instability at many levels. Utilizing a streamlined pipeline for genome-scale pooled CRISPR-Cas9 screening, the projects aim to deepen our insights into the organization and biological functions of ubiquitin and SUMO signaling networks by systematically exploring their roles in genome stability maintenance and cellular stress responses. We are also interested in how ubiquitin- and SUMO-mediated signaling promote host cell responses to viral attacks. Where relevant, CRISPR screening approaches will be complemented by mass spectrometry-based proteomic analyses. The biological functions and mechanistic basis of screen findings will be investigated by means of a wide range of approaches within cell and molecular biology, biochemistry and protein imaging that are established in our lab. The successful candidates will also have an opportunity to take part in ongoing efforts to further develop and innovate our CRISPR-Cas9 screening platform to broaden its application as a powerful discovery tool in multiple aspects of cell biology.

Qualifications
We are looking for highly motivated and ambitious candidates with:

• A PhD degree in a relevant biological subject (e.g. genome stability, cell cycle, ubiquitin/SUMO, protein signaling, chromatin, virology or related). If the PhD has not been completed, a written statement from the PhD supervisor should be provided.
• Solid experience in methodologies within cell and molecular biology, microscopy, protein biochemistry and/or bioinformatics.
• A documented publication record, preferentially with at least one first author paper in an international peer-reviewed biological journal.
• An open-minded and enthusiastic personality.
• Ability to work independently and efficiently as part of a team.
• Excellent communication skills and sound command of English, both oral and written.

Terms of employment
The employment as postdoc is a full time and fixed-term position for 2 years. Starting date is 15 September 2022 or after agreement.

Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 35,600 DKK/approx. 4,780 EUR (April 2022-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Foreign and Danish applicants may be eligible for tax reductions if they hold a PhD degree and have not lived in Denmark during the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Questions
For more information about the positions, please contact Prof. Niels Mailand (email: [email protected] ).

Foreign applicants may find this link useful: www.ism.ku.dk  (International Staff Mobility).

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application should be in English and must include the following documents all in PDF format: 

• Motivated letter of application
• CV incl. education, work/research experience, language skills and other skills relevant for the position.
• A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
• List of publications
• A maximum of 3 publications

Application deadline: 8 June 2022, 23.59 pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not fulfil the abovementioned requirements.

Recruitment process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.