Postdoc position in synapse biology, memory, and mental health

Updated: about 1 month ago
Job Type: FullTime
Deadline: 09 Feb 2021

The Nykjaer Lab at DANDRITE - The Danish Research Institute of Translational Neuroscience - and Center of Excellence PROMEMO at Department of Biomedicine, Aarhus University, is seeking an enthusiastic and talented postdoctoral fellow to study synapse biology in mental health, memory, and associated diseases as per the 1st of April 2021 or as soon as possible thereafter. The position is a 2-year full-time position, with possibility for extension.

About the research project
Our research focuses on the family of sortilin/Vps10p receptors that controls neuronal cell fate, neurodevelopment, circuit formation, and synapse biology. Having pioneered this field, we found that sortilin receptors are critical regulators of cellular signaling and trafficking, and are functionally associated with neuropsychiatric disorders and impaired memory.
The successful candidate will be part of a vibrant, international reasearch team and work on a project aiming to understand how sortilin/Vps10p receptors control mental health and memory acquisition and consolidation. Main techniques employed will include cell biology, in vivo calcium imaging, fiberphotometry for detection of neurotransmitter release, single-cell RNA sequencing, and mouse behaviour.

Research environment
The employment will be in the https://dandrite.au.dk/people/group-leaders/nykjaer-group/ Anders Nykjaer Lab at DANDRITE – The Danish Research Institute of Translational Neuroscience - and Center of Excellence PROMEMO at Department of Biomedicine, Aarhus University. https://dandrite.au.dk/ DANDRITE is the https://dandrite.au.dk/about-dandrite/the-nordic-embl-partnership/about-... Danish node of the Nordic EMBL Partnership for Molecular Medicine and is devoted to interdisciplinary approaches in basic and translational neuroscience. https://promemo.au.dk/ PROMEMO - Center for Proteins in Memory, a Danish National Research Foundation Center of Excellence, is hosted by https://international.au.dk/ Aarhus University and aims to understand the function of memory associated proteins that determines the persistence of a memory.
The experimental work will take place at the https://biomed.au.dk/ Department of Biomedicine, which employs some 450 people and covers a range of research areas within biomedicine with neuroscience being one of the main focus areas. The infrastructure is well developed with modern laboratories, core and animal facilities.

Your job responsibilities
Your main tasks will consist of:

  • Independent research of high international quality, including publication
  • Stereotactic virus injection in adult mice
  • Calcium imaging using fiberphotometry and/or miniscopes
  • Confocal microscopy – sample preparation, imaging, and image postprocessing
  • Cell culture including primary neuronal cultures
  • Classical biochemistry and molecular biology techniques

Experience with 2-photon microscopy, mouse behavior, single-cell RNA sequencing (tissue preparation, data analysis), viral mediated shRNA, and cell signaling are an advantage.

You will report to Professor Anders Nykjær.

Your competences
The candidate should have completed a PhD in neuroscience and/or biomedicine, must be fluent in oral and written English, and possess good communication and interpersonal skills as well as a strong capacity for team work.
Shortlisting will be used.

Questions about the position
Potential candidates are strongly encouraged to contact Professor Anders Nykjaer before submitting an application, email: mailto:an@biomed.au.dk an@biomed.au.dk or tel.: (+45) 2899 2384.
Your place of work will be the new https://biomed.au.dk/about-us/the-skou-building/ Skou Building, Department of Biomedicine, Hoegh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.
We expect to conduct interviews in mid-February.

Terms of employment


Application

Your application must include the following:

We refer to the faculty’s

http://health.au.dk/en/about-health/vacant-positions/recruitment-procedu...

Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.

Letter of reference
If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.

International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark http://health.au.dk/en/research/become-a-researcher-at-health/ . Aarhus University also has a Junior Researcher Development Programme. You can read more about it


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