Postdoc in Protein Chemistry and Structural Biology - DTU Chemistry

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Postdoc in Protein Chemistry and Structural Biology - DTU Chemistry
Kgs. Lyngby, Denmark
Job Description

Are you a passionate and driven researcher with a keen interest in unraveling the mysteries of the brain's serotonin production? If so, we have an exciting opportunity for you! 

Our research project is at the forefront of understanding the complex role of the 47-residue-long N-terminus in the activation of tryptophan hydroxylase isoform 2 (TPH2). TPH2 is a brain-specific, multiple domain enzyme, acting as the catalyst for the vital and rate-limiting step in serotonin synthesis. However, the structural details of the N-terminus have remained a tantalizing enigma. The N-terminus boasts a pivotal phosphorylation site that, when phosphorylated, initiates binding of 14-3-3 proteins that enhances the activity and stability of phosphorylated TPH2. The mystery deepens, as it appears that the N-terminus might be obstructing the active site. As a postdoctoral researcher on our team, you will play a crucial part in our comprehensive and meticulous investigation. In collaboration with Copenhagen University, you will employ an interdisciplinary approach that leverages expertise in NMR, small-angle X-ray scattering (SAXS), and in-silico modeling. By combining these cutting-edge techniques, you will help to reveal the intricate function of the 47-residue N-terminus in the activation of TPH2.

The opening will be available from May 1,  2024 or as soon as possible thereafter. 

Responsibilities and qualifications
You will be involved in purification and responsible for NMR and SAXS experiments that will be conducted with colleagues at Copenhagen University. You will also teach and supervise BSc and MSc student projects. You should have a solid background in protein chemistry and scattering techniques. Additional knowledge about in-silico modelling would be advantageous.

As a formal qualification, you must hold a PhD degree (or equivalent). 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2 years. 

You can read more about career paths at DTU here .

Further information 
For further information, please contact Professor Günther H.J. Peters ([email protected]).

You can read more about DTU Chemistry at

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

Application procedure 
Your complete online application must be submitted no later than 15 March 2024 (Danish time)

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Academic Diplomas (MSc/PhD – in English)
  • List of publications 
  • References

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

Apply Now
Job Info
  • Job Identification 3108
  • Job Category VIP B
  • Posting Date 02/05/2024, 02:57 AM
  • Apply Before 03/15/2024, 06:59 PM
  • Locations Kemitorvet, Kgs. Lyngby, 2800, DK

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