Postdoc in microRNA metabolism during tumorigenesis

We are seeking applicants for a postdoc position in ‘MicroRNA homeostasis during tumorigenesis’ to join us at the Department of Molecular Biology and Genetics in the Xavier Bofill De Ros lab.

Expected start date and duration of employment

The position is available from 1st of July 2023 or as soon as possible.

The position will be available for 4 years.

Job description

We are looking for applicants with interests in the biogenesis and turnover of microRNAs and its relationship to gene expression regulation during tumorigensis. Applied methods range from biophysical over biochemical to molecular biology and bioinformatics approaches.

These activities will be in close collaboration with structural biologists and physicists.

Your profile

Applicants should hold a PhD in Molecular Biology, Biochemistry, Cell Biology, Genomics, Pharmacy or related fields.

REQUIRED: At least 1 recommendation letter.

Applicants should be self-driven, motivated and capable of planning and conducting independent research while being willing to collaborate in an international and interdisciplinary team. Good communication skills in written and spoken English language are essential, and applicants should have a strong publication record with clear contributions as first author.

Your main tasks will consist of:

• Extraction of total RNA and RNA-immunoprecipitation from cell and tissue extracts
• Analysis of microRNA expression in cell and tissue lysates by Northern blot
• Analysis of gene and protein expression in cell and tissue lysates RT-qPCR and Western blot.
• Data analysis of NGS datasets such as miRNA-seq, RNA-seq and similars
• Proximity labelling proteomics (eg. APEX, BioID)
• Functional CRISPR-based screening
• Immunochemistry and immunofluorescence
• Confocal microscopy
• Animal experimentation (colony management, experimental mattings, tissue harvests, injections, small animal procedures)
• Preparation of manuscripts, animal ethics applications and grant applications
• Contribute to mentoring of junior members of the team

Who we are

Projects are carried out in the Bofill De Ros lab. The laboratory consists of a dynamic mix of experimental and computational biologists aiming to examine how the dysregulation on molecular mechanisms involved in microRNA homeostasis impact tumour development.

What we offer

The department offers:

• a well-developed research infrastructure, laboratories and access to shared equipment
• an exciting interdisciplinary environment with many national, international collaborators
• a research climate encouraging lively, open and critical discussion within and across different fields of research
• a workplace characterised by professionalism, equality and a healthy work-life balance.

Place of work and area of employment

The place of work is in our brand-new building at the ‘University City’ Universitetsparken 81, 8000 Aarhus C, and the area of employment is Aarhus University with related departments.

Contact information

For further information, please contact: Dr. Xavier Bofill De Ros, +45-22323126, xbofill@mbg.au.dk

Deadline

Applications must be received no later than March 24th, 2023.

Application procedure

Shortlisting is used. This means that after the deadline for applications – and with the assistance from the assessment committee chairman, and the appointment committee if necessary, – the head of department selects the candidates to be evaluated. All applicants will be notified whether or not their applications have been sent to an expert assessment committee for evaluation. The selected applicants will be informed about the composition of the committee, and each applicant is given the opportunity to comment on the part of the assessment that concerns him/her self. Once the recruitment process is completed a final letter of rejection is sent to the deselected applicants.

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline. Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.

Formalities and salary range

Natural Sciences refers to the

Ministerial Order on the Appointment of Academic Staff at Danish Universities under the Danish Ministry of Science, Technology and Innovation

.

The application must be in English and include a curriculum vitae, degree certificate, a complete list of publications, a statement of future research plans and information about research activities, teaching portfolio and verified information on previous teaching experience (if any). Guidelines for applicants can be found here.

Appointment shall be in accordance with the collective labour agreement between the Danish Ministry of Taxation and the Danish Confederation of Professional Associations. Further information on qualification requirements and job content may be found in the Memorandum on Job Structure for Academic Staff at Danish Universities .

Salary depends on seniority as agreed between the Danish Ministry of Taxation and the Confederation of Professional Associations.

Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.

Research activities will be evaluated in relation to actual research time. Thus, we encourage applicants to specify periods of leave without research activities, in order to be able to subtract these periods from the span of the scientific career during the evaluation of scientific productivity.

Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Read more here . Please find more information about entering and working in Denmark here .

Aarhus University also offers a Junior Researcher Development Programme targeted at career development for postdocs at AU. You can read more about it here .

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.