Laboratory technician for radiopharmaceutical research and development

Updated: 7 days ago

Applications are invited from motivated and talented individuals for a position as laboratory technician within the R&D unit of the Hevesy Laboratory at DTU Health Tech, Technical University of Denmark (DTU). The starting date is as soon as possible.

The Hevesy Laboratory is the radiopharmaceutical unit of DTU. We strive to develop new radioactive drugs for treating disease and improving the lives of patients, and we offer you an exciting possibility to join us.

The Position
As laboratory technician, you will join our efforts to develop innovative drug delivery systems for treating cancer with targeted radionuclide therapies. The position will be administered by DTU, but the work will be split 50:50 between the research group at the Hevesy Laboratory, and the radiopharmaceutical R&D program of the private company Y-mAbs Therapeutics A/S that is embedded within the Hevesy Laboratory.

You will participate in current and future projects of the research group. Our main current effort focuses on developing nanoparticle formulations of a highly potent, radioactive compound, with the aim to use these formulations to treat aggressive brain cancer. We already know that the compound works extremely well on the cellular level and in rats but in order to use it against brain cancer in humans, we need new nanoparticle based systems that can efficiently distribute and release the compound within the brain. You will participate in the development of these systems and work closely together with researchers at all levels.

With Y-mAbs Therapeutics, you will participate in the investigation, development and optimization of radiolabeled antibodies that are currently in clinical trials. These antibodies target leptomeningeal metastases from neuroblastoma and are used to treat children with this disease. Current priorities include optimization of radiolabeling yields and stability, while maintaining reactivity towards cancer cells. You will work closely together with the head radiochemist at Y-mAbs.

Further details will be provided at a potential interview.

Responsibilities & tasks
The key responsibilities of the successful candidate will include to:

  • Carry out experimental laboratory work
  • Carry out and optimize analytical procedures
  • Report results to project leadership
  • Participate in scientific discussions of results
  • Contribute to scientific articles

Qualifications
Besides have an education as laboratory technician the ideal candidate has a unique drive and motivation for research and development, and thrives in a non-static environment of uncertainty and constantly changing tasks. Laboratory experience from other research groups, research-based start-ups or small biotech companies will be highly valued.

The ideal candidate is dedicated to improving the lives of cancer patients, has a keen sense of purpose, and will go the extra mile to achieve this higher goal. Further, the ideal candidate is an out-going team player that enjoys frequent interaction with colleagues, open and honest discussion, and has the necessary confidence for independent decision-making when faced with unforeseen experimental challenges.

The following qualifications are requirements:

  • Hands-on experience with analytical HPLC, preferably including size exclusion methods
  • An excellent command of English, in speech and writing

The following qualifications will be valued but are not requirements:

  • Hands-on experience with TLC methods
  • Experience with handling radioactive materials
  • Experience with modifying or formulating antibodies or other proteins
  • Experience with organic synthesis
  • Experience with mass spectrometry
  • Experience with nanoparticles
  • Experience with preparative HPLC
  • Experience with handling laboratory animals

Note that knowledge of Danish is not a requirement.

About the Hevesy Laboratory
The Hevesy Laboratory is the radiochemical and radiopharmaceutical division within DTU Health Tech, with about 32 employees. The laboratory has a 16.5 MeV cyclotron equipped with a beam line for in-house production of radioisotopes for use in radioactive pharmaceuticals. The laboratory has chemistry and biology research laboratories and clean rooms, which feature state-of-the-art equipment for working with radioisotopes. In addition, our in-house GMP team produces radiopharmaceuticals for diagnostics and therapy, which are delivered to local hospitals as well as external collaborators. At present, the research group at the Hevesy laboratory consists of an international and dynamic team, focusing on the development of new radioactive pharmaceuticals for diagnostics and therapy. Our research is heavily interdisciplinary and features multiple collaboration partners both locally and internationally.

Salary and appointment terms
Salary and employment conditions are in accordance with the OAO-collective agreement and the organizational agreement between the Danish Ministry of Finance and HK/Stat (The National Union of Commercial and Clerical Employees). The position is full-time. The starting date may be tailored to the right candidate.

The primary place of work is The Hevesy Laboratory, Risø Campus near Roskilde, Denmark.

Application and contact
Please submit your online application no later than 18 February 2021 (Danish time). Please open the link "apply online" and fill in the application form and attach as a minimum the following mandatory documents (all in English): 

  • Motivated application letter (maximum 1 page, please specifically point out your two main skills)
  • Curriculum Vitae (if you have scientific publications or patents, please point out your contribution)

Do not hesitate to contact Senior Scientist Andreas I. Jensen by e-mail or phone for questions and further details, atije@dtu.dk , +45 2012 6187.

All interested candidates irrespective of age, gender, race, nationality, religion or ethnic background are encouraged to apply.

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 175 persons, 130 PhD students and a technical/administrative support staff of about 80 persons.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,000 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.


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