Assistant Professor in CRISPR-mediated Gene Editing Combined with…

The Centre for Exo-Adapt invites applications from outstanding candidates who are interested in joining our team as an assistant professor. The candidate will be affiliated with the Jens S. Andersen group at the Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense. The position is available for three years from Marts 2023 or as soon as possible thereafter.

The RNA Exosome
Our genome produces RNA that either gives rise to protein or to independent RNA molecules. However, genomic DNA is hyperactive, and only a fraction of the RNA produced ends up as functional molecules – the rest is degraded. The exosome complexes are the molecular machines that detect and remove undesirable RNA so that cells do not drown in their own molecular waste. The core complex of the exosome has been comprehensively studied, revealing that it is merely a general RNA degradation machine. Instead, specific recognition of its multitude of substrates is achieved by the association of the exosome with so-called protein adaptor complexes. Although some of these have been identified, we do not understand how they recognize and discriminate their substrates, how they interact with the exosome and how these interactions are regulated to achieve adequate RNA turnover at steady state or in dynamic cellular settings.

Research Project and Role
As an assistant professor in Exo-Adapt you will be involved in highly ambitious and interdisciplinary projects covering functional and structural studies of protein-RNA complexes using for example CRISPR-mediated gene editing for tagging of proteins for protein-protein interaction and protein proximity labelling analysis, fluorescence microscopy, protein and PTM analysis by mass spectrometry-based proteomics, and characterization of RNA substrates by RNA sequencing and bioinformatic approaches.

Qualifications/Requirements
We are looking for a highly motivated, enthusiastic, and ambitious candidate with:

• A PhD degree in biochemistry, biomedicine, molecular biology, protein science, analytical biochemistry, or similar field.
• Experience in CRISRP-mediated gene editing and/or mass spectrometry-based proteomics for cell biological studies.
• Proficiency in computational data analysis and statistics.
• Strong communication and collaborative skills and an interest in working in an international and interdisciplinary environment.
• An open and positive mind to contribute positively to the success of the Centre for Exo-Adapt and well-being of the research team.
• Proficiency in spoken and written English.

In addition to research, the applicant must be able to teach and advise students.

Applicants will primarily be evaluated based on their documented international scholarly and publication achievements.

Deadline
27 February 2023.

Please see the full call, including how to apply, on www.sdu.dk .