Postdoctoral Fellow - Regulation of Protein Liquid Droplets During Transcription

Brno, Czech Republic | www.ceitec.eu

We are the Czech Republic’s flagship basic research institute based at Masaryk University. Our modern in-house core facilities, which provide open access to the latest technologies and expertise, currently support more than 500 researchers from over 35 countries, who are together pushing the boundaries of knowledge in the areas of structural biology, molecular medicine, genomics and proteomics of plant systems, and neuroscience.

Our postdoctoral programme will enable you to participate in one of many exciting scientific projects addressing current global issues related to health and the quality of human life. You will have the opportunity to discuss and develop ideas and train your ability to reason in a scientific manner, formulate hypotheses independently, to innovate, and to perform independent research. It is an excellent opportunity to fully develop the skills acquired throughout your PhD studies. You will have access to a professional administration supporting you with grant preparation and administration, with technology transfer, science communication and with other areas of modern research management. You will have the chance to participate in a wide range of scientific and career development events and become a valued member of our vibrant multinational scientific community.

Cells employ protein liquid droplets to form dynamic clusters, which function as nanoreactors or storages with the increased local concentration of specific protein components. These membrane-less organelles self-assemble based on weak protein-protein interactions of intrinsically disordered domains. However, the role of specific sequences remains elusive and the mixing between different protein droplets unexplored. This project is focused on the droplets involved in genome transcription, where posttranslational modifications control the droplet composition and regulate the transcription. Expected findings are not only important for the general knowledge but could also be useful in the design of new treatments because translocation malfunction is involved in numerous diseases including cancer. The research is strongly coupled to collaborations with excellent experimental teams and will be more closely discussed during the interview. The employed tools will contain multi-scale simulations using a wide range of advanced sampling techniques and development of protein parametrization.

• PhD in computational physics/biophysics/chemistry and related fields
• Theoretical knowledge of Monte Carlo and Molecular Dynamics
• Some years of work experience in simulations with proteins/polymers, in particular disordered ones and their analysis
• Published in impactful journals in the field, corresponding to given stage of career demonstrating creativity and scientific quality
• Good English language – spoken and written
• Motivated person with collaborative mind set

We value our employees, and we support them from their very first day at CEITEC. We are an inclusive, equal opportunity employer and offer a highly collaborative, collegial and family friendly, international working environment with relocation assistance through our Welcome Office. The selected candidate will become a valued member of the CEITEC scientific community with access to in-house core facilities and professional administrative support. Have a look at what your potential peers say about working at CEITEC MU.

Brno is a lively city surrounded by beautiful countryside. It is a top destination for many educated expatriates working in the areas of science and technology. Brno is located in the heart of Europe and offers a great standard of living.

• An attractive salary condition
• Medical insurance
• 6 weeks of paid holiday
• Contribution to a pension scheme
• Flat-rate meal contributions
• A multisport card and sports lessons directly at the campus
• Reduced prices for mobile operator tariffs
• Special employee bank products

CEITEC MU is a proud holder of the European Commission’s HR Excellence in Research Award .

Application deadline: 31 October 2022

Expected start date: negotiable

Hours: full time

Duration: fixed term

Applications including a CV, list of publications, brief motivation letter, and contacts for at least two references should be sent via e-Application HERE .

In the case of any difficulties filling out the e-application, please contact [email protected]

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In justified cases, the job announcer can extend, interrupt or cancel the selection procedure.