A 3D printing as a tool to study cardiovascular system

Affiliation: Masaryk University, Faculty of Medicine
Study program: PhD program Biomedical Sciences
Specialization: Cell and Tissue Morphology
Workplace: Department of Anatomy, Faculty of Medicine
Mode: Full-time
Supervisor: Andrea Vítečková Wünschová PhD
Lab´s website:
Cooperation with Institute of Biophysics Academy of Sciences Czech Republic – webpage:
https://www.ibp.cz/en/research/departments/biophysics-of-immune-systems/...
group-of-vitecek-jan
Title: A 3D printing as a tool to study cardiovascular system
Brief annotation:
Cardiovascular diseases have a high rate of mortality and morbidity worldwide. Molecular mechanisms
causing these diseases are unclear. Preclinical studies often use animal models, however, it does not
allow high-throughput testing. Also it is difficult to study certain aspects of mentioned diseases. Thus,
in vitro models can be an interesting alternative mainly when human blood or cells are employed.
The main task of the study will be focused on preparation of 3D printed models with brain aneurysm
due to starting AZV grant Blood Flow Modelling in Intracranial Vessels in Relationship to Endothelium
Changes and Development of Intracranial Aneurysm. Stenosis and ischemic cerebrovascular diseases
will be studied next to it and are focus of another AZV grant NV19-04-00270 Assessment of emodynamic
Parameters of Stable and Unstable Atherosclerotic Plaques in the Carotid Arteries in in vitro Models.
Funding:
AZV grant starting this year 2022 called Blood Flow Modelling in Intracranial Vessels in Relationship to
Endothelium Changes and Development of Intracranial Aneurysm. The supervisor is a holder of this
grant.
Requirements:
Due to interdisciplinary topic a student should be proficient in molecular biology methods such as realtime
PCR or biochemical methods or 3D printing or hemodynamics. It is necessary to be interested in
other mentioned methods and willing to learn. Creativity is very welcome. The student should be able
to communicate in English to be able to publish papers and to be part of exchange programs abroad.