Senior Staff Scientist (Medicinal Chemistry)

Date Posted: 09/15/2023
Req ID:33974
Faculty/Division: Faculty of Arts & Science
Department: Acceleration Consortium
Campus: St. George (Downtown Toronto)

Description:

The Acceleration Consortium (AC) at the University of Toronto (U of T) is leading a transformative shift in scientific discovery that will accelerate technology development and commercialization. The AC is a global community of academia, industry, and government that leverages the power of artificial intelligence (AI), robotics, materials sciences, and high-throughput chemistry to create self-driving laboratories (SDLs), also called materials acceleration platforms (MAPs). These autonomous labs rapidly design materials and molecules needed for a sustainable, healthy, and resilient future, with applications ranging from renewable energy and consumer electronics to drugs. AC Senior Staff Scientists will advance the field of AI-driven autonomous discovery and develop the materials and molecules required to address society's largest challenges, such as climate change, water pollution, and future pandemics.

The Acceleration Consortium (AC) promotes inclusive research environment and supports the EDI priorities of the unit.

Hiring is occurring on a rolling intake. Please apply ASAP and do not wait for the listed job closing date.

The Acceleration Consortium received a $200M Canadian First Research Excellence Grant  for seven years to develop self-driving labs for chemistry and materials, the largest ever grant to a Canadian University. This grant will provide the Acceleration Consortium with seven years of funding to execute its vision.

The AC is developing seven advanced SDLs. These include:

This job posting is for a Staff Scientist position within SDL3: Medicinal Chemistry.

Expertise in one or more of the following areas is desired:

Medicinal chemistry / drug discovery with chemical probes

• Protein biophysics / biochemistry
• Mass spectrometry (including affinity selection-MS)
• Controlled release properties and processes
• Organic synthesis of medicinal compounds / drugs

AI / computational / automation expertise (an asset)

• Machine learning in life sciences
• Robotics and automation
• High-throughput experimentation

The Senior Staff Scientists will work with a diverse team of leading experts at the U of T and the University Hospital Network (UNH), including: Dr. Cheryl Arrowsmith and Prof. Rob Batey.

The Senior Staff Scientists involved in the AC are highly skilled and experienced researchers who will work independently to develop the AI and automation technologies required to build robust and scalable self-driving labs, manage these SDLs, and design and implement research programs (based on the direction of the AC’s scientific leadership team) that leverage the SDL platforms to discover materials and molecules.

Senior Staff Scientists will play a leadership role within the AC research enterprise; and set objectives and directions for a subgroup of Staff Scientists. These positions involve a significant degree of autonomy and latitude on how to achieve the ambitious goals of the AC. This role will report to the Academic Director and Executive Director of the Acceleration Consortium. We are looking for individuals with diverse backgrounds and expertise to support the development of self-driving labs and materials discovery.

The components and duties of the work include:

Working with the AC community, including faculty and partners to determine the required capabilities of the SDLs to be built. Developing the plans for SDLs that will meet user requirements and designing novel instruments for automated material synthesis and characterization. Developing customized hardware and Python software packages to build SDLs. Selection, procurement, and installation of the equipment required for SDLs.

Working with the department of Chemistry, Facilities and Operations, and AC research staff to ensure that the AC labs are fully operational.

• Overseeing the activity of the laboratory technicians servicing the labs
• Supporting the selection, procurement, and installation of equipment
• Managing laboratory budgets
• Scheduling and coordinating lab access

Working as a co-investigator, in partnership with the Principal Investigator, independent management, development, and execution of research programs that leverage the AC’s SDLs and supports the research objectives of AC faculty and industry partners. Using SDLs to synthesize and characterize large quantities of candidate molecules, calibrating theoretical models with experimental data, predicting promising candidates with computational tools and machine learning algorithms, and elucidating structure-property relationships of emerging molecules, polymers, solid-state materials, formulations, etc.

Tasks include:  

• Managing the research and development projects of AC’s industry partners when implemented in AC labs.
• Developing plans that support research collaborations and planning and estimating financial resources required for programs and/or projects.
• Supervising the work of Staff Scientists, Software Engineers, Research Associates, and Post-doctoral Fellows.
• Working with Product Managers to ensure research outcomes meet partner requirements.
• Monitoring and reporting on relevant research activity to the Academic Director and Executive Director.
• Promoting AC’s research capacity, including delivering presentations at conferences.
• Collaboration in the preparation and submission of research proposals to granting agencies and progress reporting. 
• Preparing manuscripts for submission to peer review publications/journals and stewarding them through the process.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.

MINIMUM QUALIFICATIONS:

Education – Ph.D. in chemistry, materials science, life sciences, physics, engineering, robotics, computer science, or related discipline

Experience

• Over 10 years of experience in research and development 
• Experience working closely with a Principal Investigator or as a Principal Investigator, or as a Project Director with responsibilities of managing, developing and executing a major research project
• Strong experience and expert knowledge of AI and automation.
• Experience with the development of self-driving laboratories and overseeing the activities of a lab
• Experience working with industry partners and on industry lead research and development projects
• Strong experience presenting research at academic conferences
• Experience managing research staff
• Experience managing a laboratory budget and procuring equipment
• Must have a strong scholarly publication record

Skills

• Strong and effective communicator in oral and written English
• Collegial in working with team members and collaborators
• Ability to work independently

Other  

Demonstrated success in the writing and preparation of manuscripts, presentations, reports, briefs, and scientific abstracts and manuscripts for peer-reviewed journals.

Closing Date: 02/29/2024, 11:59PM ET
Employee Group: Research Associate
Appointment Type: Grant - Continuing
Schedule: Full-Time
Pay Scale Group & Hiring Zone: 150K - 180K (salary will be assessed based on skills and experince)
Job Category: Research Administration & Teaching