Research Associate

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Department of Chemistry (Professor Masad Damha)

Position Summary:

The Research Associate in Oligonucleotide Chemistry will be responsible for developing methods for the chemical and enzymatic synthesis of oligonucleotides (DNA, RNA) and their analogues at McGill University Department of Chemistry under the supervision of Prof. Masad J. Damha.  The incumbent is expected to work

collaboratively with a multi-disciplinary team to support the progression of oligonucleotide synthesis.  We are searching for an enthusiastic individual who is self-driven with a proven track record of scientific excellence with demonstrated success in research. Responsibilities will include:

•  Carry out oligonucleotide synthesis on solid supports (small and large scale, including high-throughput syntheses).
•  Solution-phase synthesis of nucleosides and nucleotides and derivatives.
•  Purification and characterization of products (HPLC, PAGE, UV, NMR, CD)
•  Conduct in vitro, and cell-based assays
• Participate in grant proposal, and patent writing
•  Work with and assist graduate and undergraduate students
•  Participate and present at group meetings

Qualifications:

   •        Solution phase synthesis of sugars, nucleosides, phosphoramidite building blocks, nucleoside triphosphates, linkers, and other related compounds, particularly fluorinated nucleosides.

    •        Solid phase synthesis and purification of RNA, DNA, and modified oligonucleotides.

    •        Measurement and interpretation of NMR spectra (1H, 13C, 19F, 31P); assignment of signals for the new compounds.

    •        Analysis of MS- and LC/MS-spectra of the new nucleosides and

    oligonucleotides.

    •        Measurement and interpretation of UV-Vis and CD spectra of modified oligonucleotide sequences paired to complementary DNA or RNA.

    •        Molecular dynamic calculations of nucleic acids

    •        Development of an assay to monitor enzymatic activities.

    •        Proficiency in PCR, and biotin-streptavidin purifications.

    •        Glovebox manipulations.

Experience and education: PhD degree in Bioorganic Chemistry, including postdoctoral and/or industrial experience.

How to Apply:

• External candidates (no current or active working appointments with McGill), utilize your personal email address and NOT your mail.mcgill.ca address or mcgill.ca) to create a profile through the external link: https://mcgill.wd3.myworkdayjobs.com/mcgill_careers

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Hourly Salary:

$28.44

Hours per Week:

35 (Full time)

Location:

Pulp&Paper Rsrch Ctr

Supervisor:

Professor

Position Start Date:

2023-01-13

Position End Date:

2024-02-28

Deadline to Apply:

2023-01-23

McGill University hires on the basis of merit and is strongly committed to equity and diversity within its community. We welcome applications from racialized persons/visible minorities, women, Indigenous persons, persons with disabilities, ethnic minorities, and persons of minority sexual orientations and gender identities, as well as from all qualified candidates with the skills and knowledge to productively engage with diverse communities. McGill implements an employment equity program and encourages members of designated groups to self-identify. Persons with disabilities who anticipate needing accommodations for any part of the application process may contact, in confidence, [email protected] .