The project aims to investigate DNA damage mechanisms involved in the premature aging of patients with deficiencies in DNA repair processes, notably Cockayne syndrome (CS) and xeroderma pigmentosum (XP). induced pluripotent cells (iPS) and organoids from affected patients will be evaluated. Thus, we will seek to correlate endogenous DNA damage with cellular phenotypes that identify problems related to the aging process. Identification of markers for the process will be extremely valuable.
Candidates must have previous experience in human cell culture, and preferentially iPS cell cultures. Must also know cell and molecular biology, and demonstrate previous work on DNA repair processes in animal cells. Experience in methodologies for detecting DNA damage, cell, and mitochondrial metabolism, and assessing the formation of oxygen radicals (ROS) in cells will also be considered.
Applicants must send to Professor Menck, via email DNArepaircoregenome@gmail.com , the following documents: 1. updated curriculum vitae, 2. letter of intent indicating their previous experience with the project themes, 3. two letters of recommendation and 4. a work plan of about two pages describing how the candidate can contribute to the study of DNA damage accumulation in stem cells and organoids, as well as their consequences.
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