Postdoctoral researcher: Inflammasome signaling

Postdoctoral researcher: Inflammasome signaling

15/11/2022

Location

Ghent, Belgium

Vacancy

About the lab

A postdoc position is available in the group of Prof. Mo Lamkanfi at the Ghent University Department of Internal Medicine and Pediatrics, located at the Medical Research Building 2 of the Ghent University Hospital Campus in Ghent, Belgium. The Lamkanfi lab, also called the Laboratory of Medical Immunology, focuses on the characterization of inflammasome signalling and lytic cell death pathways that contribute majorly to chronic inflammatory diseases and play a crucial role in host defense against microbial pathogens. Where possible, the research group aims to translate the fundamental knowledge generated into the design of novel therapeutic and diagnostic tools (e.g. PMID: 32312770; PMID: 31525186).

Job description

The Lamkanfi lab has a longstanding interest in inflammasome mechanisms and their roles in human diseases.You will work on a granted project of the Research Foundation – Flanders that aims to define and characterize novel signaling pathways that modulate inflammasome activation and pyroptosis induction in novel mouse models of inflammatory diseases and in primary hematopoietic and epithelial cells of human and murine origin. The successful applicant will also apply retroviral transduction and CRISPR/Cas9-based screening technologies to discover new regulators of inflammasome activation in primary cell systems.

Profile

Essential

• You have a Ph.D. degree in Biochemistry, Molecular Biology, Bio-engineering, Biotechnology or equivalent.
• You have excellent English communication skills (both oral and written).
• You have (a) first author publication(s) in high ranking journals from your PhD work.
• You have a FELASA B/C degree or equivalent degree accreditation for animal studies.
• You can plan and conduct research independently and accurately.
• You can function well in a team as you will be integrated into the international collaborative research environment of the host laboratory.
• You can take initiative and have a hands-on mentality, perseverance and critical mind-set.
• You have a keen interest in genetic engineering and cell death biology.

Desirable but not required

• Experience from PhD and/or postdoc research in retroviral transduction, CRISPR/Cas based gene editing, and/or cell death or inflammasome biology is an asset, as well as a publication record in peer-reviewed journals showing expertise in these areas.
• Hands-on experience in RNA sequencing or other NGS workflows is an asset.
• Experience in guidance of master and/or PhD students is an asset.

We offer

• A full time post-doc position in the Lamkanfi lab that is extendable for up to 3 years pending positive evaluation.
• A competitive remuneration based on research experience will be determined by salary scale PD1 to PD4. Click here for more information about our salary scales .
• An exciting and innovative project, covering a fascinating combination of technologies and research interests, and aimed at discovering novel inflammasome modulating pathways in myeloid and epithelial cell types.
• Access to state-of-the art tools and infrastructure within an excellence-based research institute.
• A stimulating and supportive international research environment.
• Various training opportunities are organized at Ghent University to broaden your expertise and skills as a postdoc (https://www.ugent.be/en/work/mobility-career/postdoc-talent-management/postdoctrainingprogram.htm ).
• All Ghent University staff members enjoy a number of benefits, such as a wide range of training and education opportunities, 35 days of holiday leave (on an annual basis for a full-time job) supplemented by annual fixed bridge days, bicycle allowance and eco vouchers. Click here for a complete overview of all the staff benefits (in Dutch).

How to apply?

The position is immediately available. Applications are welcome until the position is filled.

For more information please contact Prof. dr. Mo Lamkanfi (Mohamed.Lamkanfi@ugent.be ).

Please include a single pdf in your application that combines the following elements:

• 1-page motivation letter expressing your interest in and suitability for the project
• 1-page summary of past research activities
• Detailed CV including publication list
• A transcript of your PhD and FELASA degrees
• Contact information of 2-3 referees

The first review of applications will start immediately. A shortlist of applicants will be selected and invited for interviews.

As Ghent University maintains an equal opportunities and diversity policy, everyone is encouraged to apply for this position.