Postdoctoral researcher Cancer Immunology and Lipid Metabolism in the Tumor Immune Microenvironment

Updated: 24 days ago

The Faculty of Sciences and Bioengineering Sciences, Department Department of Bioengineering Sciences, is looking for a postdoctoral researcher

More concretely your work package contains: 

Context:

The Jo Van Ginderachter lab is looking for an excellent postdoctoral scientist interested in understanding the mechanisms that regulate the heterogeneity and pro-tumoral activity of tumor-associated macrophages, and how we can use such mechanisms to optimize immunotherapy. In particular, we want to understand how lipids and altered lipid metabolism regulate tumor-associated macrophages and whether we can reprogram the macrophages by interfering with lipid metabolism.
This project is embedded in an ambitious, excellence-based research consortium on strategic basic research with an economic finality (FWO-SBO program LipoMacs) consisting of six Flemish partners (Jo Van Ginderachter-VIB/ Vrije Universiteit Brussel, Johan Swinnen-KULeuven, Massimiliano Mazzone- VIB/KULeuven, Jerome Hendriks-UHasselt, Charlotte Scott, VIB/UGent). You will be an active part of this consortium and will interact and collaborate with the other partners.
The project relies on cutting-edge lipidomics, spatial lipidomics and spatial multiomics technologies to map the heterogeneity of macrophages at the level of lipid metabolism. This project is also further supported by a bioinformatician in the JVG lab.
The JVG lab is located at the Science/Humanities campus of the Vrije Universiteit Brussel, in the center of Brussels and in the heart of Europe, and is part of the excellence-based VIB Center for Inflammation Research (director: Bart Lambrecht).

Selected references:

  • Geeraerts X, Fernandez-Garcia J, …, Van den Bossche J*, Fendt SM*, Van Ginderachter JA*. *Equal contribution. Macrophages are metabolically heterogeneous within the tumor microenvironment. Cell Reports 2021, doi: 10.1016/j.celrep.2021.110171;
  • Pombo Antunes AR, Scheyltjens I, ...Van Ginderachter JA*, Movahedi K*. *Equal contribution. Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience 2021, doi: 10.1038/s41593-020-00789-y;
  • Van Damme H, …, Laoui D*, Van Ginderachter JA*. *Equal contribution. Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. Journal for Immunotherapy of Cancer 2021, doi: 10.1136/jitc-2020-001749;
  • Bieniasz-Krzywiec P, …, Van Ginderachter JA, Mazzone M. Podoplanin-expressing macrophages promote lymphangiogenesis and lymphoinvasion in breast cancer. Cell Metabolism 2019, doi: 10.1016/j.cmet.2019.07.015;
  • Laoui D, Keirsse J, ..., Van Ginderachter JA. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. Nature Communications 2016. doi: 10.1038/ncomms13720. 

For this function, our Brussels Humanities, Sciences & Engineering Campus (Elsene) will serve as your home base. 


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