In this project, the engineering of zonated organoid-based implants for osteochondral defect regeneration is foreseen. Candidates with a cell biology background (particularly regenerative medicine, organoids, iPSCs, MSCs), interested in turning engineers and expand their skills in automated end-to-end biomanufacturing of organoid-based implants for osteochondral defect regeneration are welcome to apply. This is a genuinely multidisciplinary EU project at KU Leuven aiming to make an impact and translate Tissue Engineered implants into predictively functioning living products (ATMPs), paving the way for clinical application. The first phase of this project aims to employ novel bioreactors developed by an industrial partner for skeletal spheroid culture and chondrogenic differentiation. Subsequently, an entire automated platform integrating bioreactors with robotics and bioprinting will be setup to allow culture of higher number of spheroids with minimal manipulation. Your tasks will involve:
- Culture and characterization of stem cell derived cartilaginous spheroids.
- Set up and operation of automation devices (e.g. liquid handling systems).
- Scale-up of tissue implants and interfacing with the preclinical validation team.
- Management of workflow in the Jointpromise EU-H2020 consortium.
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