At the VIB-VUB Center for Structural Biology (Vrije Universiteit Brussel / VIB), we are looking for a highly qualified and motivated postdoctoral researcher with a strong background in Cryo-EM and/or X-ray crystallography, biochemistry and biophysics, and interested in biochemical and structural studies on bacterial persistence pathways.
Project description:
Due to the development of resistance to antibiotics, bacterial infections are becoming more life-threatening every year. In addition to resistance, bacterial persistence offers an important means to avoid clearance of infections. Persisters are formed by phenotypic switching to an antibiotic-tolerant state, rendering a small subset of cells within an isogenic population capable of surviving antibiotic treatment. Within this ongoing research project we want to gain more insight into the mechanisms of persistence by unravelling the associated molecular pathways down to atomic resolution (e.g. Verstraeten et al. Mol. Cell 2015; Gkekas et al. J. Biol. Chem . 2017; Verstraeten et al. Mol. Microbiol. 2019). The project is part of an interdisciplinary Excellence of Science program in collaboration with the teams of Jan Michiels, Régis Hallez, Françoise Van Bambeke, Steven Ballet and Jörg Vogel. Within this consortium you will use single particle cryo-EM and X-ray crystallography, in combination with biophysical methods and enzyme kinetics, to gain insight in the role of important persistence proteins and their interactions. This information will subsequently be used to intervene with these proteins and processes to devise new potential therapeutic strategies.
For more information about the Versées lab see https://verseeslab.sites.vib.be/en
Required skills and experience:
- PhD in Biochemistry, Molecular Biology, Bio-engineering or equivalent
- Strong background in protein expression, purification and characterization
- Experience in Cryo-EM and/or X-ray crystallography is mandatory
- Proficient in written and spoken English
- Strong organizational and interpersonal skills
Contact:
Please send applications (including CV, research experience, and at least two names and contact information for references) to:
Wim Versées, VIB-VUB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel - [email protected] .
About CSB:
The VIB-VUB Center for Structural Biology focusses on the structure and dynamics of macromolecular complexes in health and disease. Our multidisciplinary team of about 100 researchers is housed in new laboratory facilities and combines extensive expertise in structural biology (state of the art in-house cryo-EM, X-ray crystallography, NMR, SAXS, and atomic force microscopy), biophysics, enzymology and molecular biology.
Similar Positions
-
Associate Researcher Cryo Em (Pa2024/1028) , University of Lund, Sweden, 1 day ago
Lund University was founded in 1666 and is repeatedly ranked among the world’s top universities. The University has around 47 000 students and more than 8 800 staff based in Lund, Helsingborg and ...
-
Associate Researcher Cryo Em, SciLifeLab, Sweden, about 20 hours ago
Medicinska fakulteten, Institutionen för experimentell medicinsk vetenskap Lund University was founded in 1666 and is repeatedly ranked among the world’s top universities. The University has aroun...
-
Postdoctoral Fellow, European Molecular Biology Laboratory, France, 9 days ago
10 Apr 2024 Job Information Organisation/Company European Molecular Biology Laboratory Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Country France Application D...
-
Postdoctoral Researcher, Vrije Universiteit Brussel (VUB), Belgium, about 1 month ago
19 Mar 2024 Job Information Organisation/Company Vrije Universiteit Brussel (VUB) Research Field Chemistry » Biochemistry Chemistry » Inorganic chemistry Chemistry » Other Engineering » Other Rese...
-
Associate Researcher Cryo Em, Lunds universitet, Sweden, 11 days ago
7 Apr 2024 Job Information Organisation/Company Lunds universitet Department Medicinska fakulteten, Institutionen för experimentell medicinsk vetenskap Research Field Medical sciences » Other Rese...
-
Researcher, Vrije Universiteit Brussel (VUB), Belgium, 14 days ago
5 Apr 2024 Job Information Organisation/Company Vrije Universiteit Brussel (VUB) Research Field Computer science » Programming Computer science » Other Engineering » Industrial engineering Researc...