Postdoc in Cancer Immunology and Lipid Metabolism in the Tumor Immune Microenvironment

Updated: about 10 hours ago

Description

The Jo Van Ginderachter lab is looking for an excellent postdoctoral scientist interested in understanding the mechanisms that regulate the heterogeneity and pro-tumoral activity of tumor-associated macrophages, and how we can use such mechanisms to optimize immunotherapy. In particular, we want to understand how lipids and altered lipid metabolism regulate tumor-associated macrophages and whether we can reprogram the macrophages by interfering with lipid metabolism.

This project is embedded in an ambitious, excellence-based research consortium on strategic basic research with an economic finality (FWO-SBO program LipoMacs) consisting of six Flemish partners (Jo Van Ginderachter-VIB/ Vrije Universiteit Brussel, Johan Swinnen-KULeuven, Massimiliano Mazzone- VIB/KULeuven, Jerome Hendriks-UHasselt, Charlotte Scott, VIB/UGent). The candidate will be an active part of this consortium and will interact and collaborate with the other partners.

The project relies on cutting-edge lipidomics, spatial lipidomics and spatial multiomics technologies to map the heterogeneity of macrophages at the level of lipid metabolism. This project is also further supported by a bioinformatician in the JVG lab.

The JVG lab is located at the Science/Humanities campus of the Vrije Universiteit Brussel, in the center of Brussels and in the heart of Europe, and is part of the excellence-based VIB Center for Inflammation Research (director: Bart Lambrecht).

Selected references:

Geeraerts X, Fernandez-Garcia J, …, Van den Bossche J*, Fendt SM*, Van Ginderachter JA*. *Equal contribution. Macrophages are metabolically heterogeneous within the tumor microenvironment. Cell Reports 2021, doi: 10.1016/j.celrep.2021.110171.

Pombo Antunes AR, Scheyltjens I, ...Van Ginderachter JA*, Movahedi K*. *Equal contribution. Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience 2021, doi: 10.1038/s41593-020-00789-y

Van Damme H, …, Laoui D*, Van Ginderachter JA*. *Equal contribution. Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. Journal for Immunotherapy of Cancer 2021, doi: 10.1136/jitc-2020-001749

Bieniasz-Krzywiec P, …, Van Ginderachter JA, Mazzone M. Podoplanin-expressing macrophages promote lymphangiogenesis and lymphoinvasion in breast cancer. Cell Metabolism 2019, doi: 10.1016/j.cmet.2019.07.015

Laoui D, Keirsse J, ..., Van Ginderachter JA. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. Nature Communications 2016. doi: 10.1038/ncomms13720


Profile
  • Ph.D. in biology, bio-engineering sciences, medical sciences, biomedical sciences, or related disciplines
  • Solid publication record
  • Experienced in immunology, preferably myeloid cell biology and/or metabolism of immune cells
  • Experienced in working with mouse models (FELASA B or C required)
  • Experience with flow cytometry and lipidomics or other omics technologies is highly beneficial
  • Experience in tumor immunology is beneficial
  • Excellent spoken and written English skills
  • Creative, highly motivated, independent, team player

 We offer
  • The possibility to independently lead your research project, but with sufficient guidance and mentoring
  • Excellent training conditions, with the possibility to learn a wide set of cutting-edge technologies
  •  A friendly, dynamic, and scientifically stimulating working environment, with a team of highly motivated scientists
  • Long-term career opportunities
  • Funding for up to 4 years. However, you will be encouraged to also apply for personal fellowships

Starting date

1 October 2022


How to apply?
  • A detailed CV, containing a full list of publications
  • Motivation letter 
  • Summary of past research
  • Names and contact information of 2-3 referees

For additional information on the position contact Prof. Dr. Jo Van Ginderachter (jo.van.ginderachter@vub.be)


View or Apply

Similar Positions