(ref. BAP-2021-657)Laatst aangepast : 23/08/2021
To decipher the gene regulatory logic of pre-implantation and early post-implantation human embryo development. The Pasque Lab is a molecular and cellular biology research group based at KU Leuven, University of Leuven, Department of Development and Regeneration, Belgium. Our research focuses on understanding epigenetic reprogramming in cells, development and diseases. We are interested in understanding how the identity of one type of somatic cell can be reprogrammed to another type. We want to know how modifications of DNA, chromatin and RNA help to maintain cell identity, are reversed and re-established during cell fate reprogramming as well as how they may become eroded in diseases. We use a variety of cell fate reprogramming systems including somatic cell reprogramming to induced pluripotent (iPS) cells, mammalian pluripotent stem cells and embryos. We employ molecular, biochemical and cellular approaches as well as modern transcriptomic and epigenomic approaches, combined with genetic and epigenetic editing to dissect the molecular mechanisms of cell fate control. Understanding epigenetic reprogramming could help us to better direct cell fate for regenerative medicine, to understand the molecular basis of embryo development and hallmarks of several human diseases including cancer.
The Laboratory of Cellular Reprogramming and Epigenetic Regulation at the KU Leuven is seeking a highly motivated postdoc to study cell fate specification in human pre-implantation and early post-implantation embryogenesis. Your goal will be to identify factors and the gene regulatory logic underlying the induction of human trophoblast cell fates. To this end, you will use human pre-implantation embryos and imaging, stem cell-based embryo models (2D, 3D), single-cell transcriptomics plus chromatin accessibility assays, genome engineering and computational biology approaches. You will explore the functional significance of candidate regulators of human trophoblast development recently identified in the Pasque lab.
- PhD degree in Life Sciences, Bioinformatics, Bioscience Engineering or related.
- Experience with cell culture, molecular biology, transcriptomics, epigenomics, early mammalian embryogenesis, human pluripotent stem cells is a plus
- Postdoc position in a young international team at the KU Leuven
- The KU Leuven (University of Leuven) is located in the city of Leuven, a historic, international, dynamic and lively city at the center of Belgium and Europe. The KU Leuven is currently placed amongst the best universities in the world by the Times Higher Education and has been deemed as Europe's most innovative university for 3 years in a row.
- Modern facilities, beyond state-of-the-art technologies and infrastructure
- You will join the recently founded KU Leuven Single-Cell Omics Institute
- The position is immediately available
- Stimulating and collegial research environment
- You will join a young and motivated international team with an outstanding network of collaborations
- Exceptional healthcare benefits
For more information please contact Mrs. Christina Vochten, tel.: +32 16 33 02 95, mail: firstname.lastname@example.org.
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
Postdoc (3 Yr) Intracellular Notch Trafficking And Stem Cell Fate, Maastricht University (UM), Netherlands, 15 days ago
Background: Notch proteins are master regulators of cell fate during development and control cell renewal and differentiation in most adult tissues. Activation of Notch proteins is regulated by su...
Research Assistant (Ph D Student), University of Bucharest, Romania, 6 days ago
-PhD student in Biology; - Bachelor in Biomedical field; - at least 2 years of research experience in the Biomedical field; - experience in: establishment of normal and/ or tumor cell cultures, ma...
Postdoctoral Scientist To Work On Neuronal Development, VIB, Belgium, about 10 hours ago
Job description The Laboratory of Interneuron Developmental Dynamics (headed by Lynette Lim) is part of the VIB-KU Leuven Center for Brain & Disease Research and is located on Campus Gasthuisberg...
Postdoctoral Researcher – Automated & Organoid Based Skeletal Tissue Engineering, KU Leuven, Belgium, 8 days ago
In this project, the engineering of zonated organoid-based implants for osteochondral defect regeneration is foreseen. Candidates with a cell biology background (particularly regenerative medicine...
Postdoctoral Position (Biologist) To Study Tumor States During Cancer Progression, Metastasis And..., Université libre de Bruxelles, Belgium, 15 days ago
Our laboratory is studying the mechanisms regulating stem cells and tumor heterogeneity (See recent publications: Sánchez-Danés Nature 2016, Latil, Cell Stem Cell 2017, Sánchez-Danés Nature 2018, ...
Postdoc On "Tissue Specific Responses To Dna Damage Induced Transcription Stress", Erasmus MC (University Medical Center Rotterdam), Netherlands, about 8 hours ago
Correct transcription by RNA polymerase II (Pol II) to generate RNA is crucial for proper cell function. However, transcription is continuously compromised by DNA damage. These transcription-block...