Currently, the success of organ transplantation is hampered by a shortage of suitable organ grafts and the adverse effects of ischemia reperfusion injury (IRI). IRI, or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue after a period of lack of oxygen supply. The consequence of IRI is oxidative stress. This oxidative stress can kill cells in an iron-dependent way, known as ferroptosis. Ferroptosis will result in inflammation and cell death in the transplanted organ, caused by the activation of the immune system, and this can lead to primary graft dysfunction.
We will use a novel ferroptosis inhibitor to block IRI during preservation of the organ grafts. This project is supported by Research Foundation Flanders (FWO) and is a high-level collaborative project with the UAntwerp.
Your project will focus on setting up small animal models for ischemia reperfusion injury of abdominal organs (kidney and liver) and evaluating the effect of ferroptosis inhibitors on IRI.
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