Bioinformatician/computer scientist for single-cell multiomic analysis

Updated: about 1 month ago

The Faculteit Geneeskunde en Farmacie, Department Basis (bio)-medische wetenschappen, is looking for a predoctoral researcher

More concretely your work package contains: 

The Movahedi lab at the Vrije Universiteit Brussel is looking for a bioinformatician or computer scientist to join our team. You will play a key role in our ambition to develop new treatment paradigms for neurodegenerative diseases of the brain. By relying on innovative technologies, we aim to understand how immune cells modulate brain disorders and how they can be engineered to ameliorate disease. Our research heavily draws on single-cell omics profiling and gene editing technologies, for which bioinformaticians and AI specialists are essential. Your responsibility will be to implement and develop analysis pipelines for these state-of-the-art methodologies. This will include single-cell multiomic spatial profiling and CRISPR-sequencing. You will further implement algorithms that offer predictions on putative biological functions, cell-cell interactions, cellular differentiation trajectories and the gene regulatory networks that drive cellular identity and activation.

Our lab is located at the university medical campus of the Vrije Universiteit Brussel (Jette campus), in the hearth of Europe. You will join a dynamic and ambitious team of highly motivated international scientists, in a friendly environment where you can thrive both at a professional and personal level. Long-term career opportunities and mentoring are part of the package.

Funding is available via the ERC consolidator grant ReplaceMi. We offer an initial full-time 2-year position that can be renewed. 

Relevant publications of our lab

De Vlaminck et al. Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation. Immunity 2022. PMID: 36228615

Scheyltjens et al.  Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues. Nature Protocols 2022. PMID: 35931780  

Lodder et al. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta Neuropath Comm 2021. PMID: 34103079

Pombo Antunes et al. Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience 2021. PMID: 33782623

Van Hove H et al. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nature Neuroscience 2019. PMID: 31061494

For this function, our Brussels Health Campus (Jette) will serve as your home base. 

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