Postdoctoral Research Associate in Glioblastoma Cell Biology/Pharmacology

• Full time fixed term opportunity for 2 years with the possibility of extension

• Opportunity to work on cancer dormancy and contribute to the successful translation of a novel glioblastoma drug candidate

• Base Salary $95,047- $105,305+ 17% superannuation

About the opportunity

An exciting post-doctoral position is available in the A/Prof Lenka Munoz’ laboratory to study the mechanism of cancer dormancy and drug tolerance in glioblastoma. Our laboratory has developed and is now translating a new class of cancer drugs into glioblastoma clinical trials. However, glioblastoma tumours contain a small population of drug-tolerant persister cells that evade the effects of drugs by entering a dormant state. To develop therapeutic approaches with full clinical impact, we need to understand the mechanism of dormancy and drug tolerance in glioblastoma. The successful applicant will work on a NHMRC-funded project focused on the delineation of dormancy mechanism and pharmacological exploitation of new targets in drug-tolerant persister cells.

Our laboratory is located in the multi-disciplinary Charles Perkins Centre (CPC) at the main campus of the University of Sydney. CPC provides an outstanding intellectual environment and access to a wide range of cutting-edge technologies in cell imaging, cytometry, genomics and proteomics. The successful applicant will have superb  opportunities to expand their expertise and/or take advantage of the diverse knowledge of the CPC community, and incorporate it into their research project.

Your key responsibilities will be to:

• communicate with key internal and external stakeholders and engage with collaborators at the University of Sydney and nationally

• undertake research using glioblastoma stem cells, molecular biology techniques (incl. CRISPR), live-cell imaging and microscopy, and a variety of pharmacological/phenotypic assays

• demonstrate excellence in data analysis, interpretation of results and directing future experiments

• assist with preparation of manuscripts and competitive research grants

• support the supervision of undergraduate and postgraduate students

• interpret and present data to collaborators, develop profile through presentations at conferences and seminars.

About you

The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Postdoctoral Research Associate who has:

• a PhD in cell/molecular biology or pharmacology or a related discipline (awarded or near completion) 

• background in cancer cell biology and hands-on experience conducting cell-based research, preferably with cancer stem cells

• experience in cell/molecular biology techniques such as CRISPR, RNA interference, PCR, Western blotting and immunofluorescence

• experience with platforms such as Incucyte, Opera Phoenix, flow cytometry to perform phenotypic assays (e.g.; viability, apoptosis, cell cycle, 3D spheroid growth)

• familiarity with sequencing technologies and ability to analyse sequencing and -omics datasets (desirable, but not required)

• recognised contributions to the preparation and analysis of research data, drafting reports and manuscripts

• ability to work effectively within a team and excellent organizational, interpersonal, and communication skills (both verbal and written).

To apply for this position, please address the below statements in a cover letter that you attach to your application:

• outline your experience in performing and/or analyzing sequencing and/or -omics datasets

• outline your current research interests and your plans for your reearch trajectory

• what do you see as being the key current challenge in the identification and validation of novel cancer drug targets

Closing date for applications

11.59pm, Tuesday 16 November 2021

Sponsorship / work rights for Australia

Visa sponsorship is only available for this position for candidates who are currently located within Australia.

Australian Temporary Residents currently employed at the University of Sydney may be considered for a fixed term contract for the length of their visa, depending on the requirements of the hiring area and the position.

Pre-employment checks

Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.

EEO statement

The University of Sydney is committed to diversity and social inclusion. Applications from people of culturally and linguistically diverse backgrounds; equity target groups including women, people with disabilities, people who identify as LGBTIQ; and people of Aboriginal and Torres Strait Islander descent, are encouraged.

How to apply

Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.  

For employees of the University or contingent workers, please login into your Workday account and navigate to the Career icon on your Dashboard.  Click on USYD Find Jobs and apply.

For a confidential discussion about the role, or if you require reasonable adjustment or support filling out this application, please contact Linden Joseph or Rebecca Astar, Recruitment Operations, at [email protected]

© The University of Sydney

The University reserves the right not to proceed with any appointment.

Closing Date: 16 November 2021

• Full time fixed term opportunity for 2 years with the possibility of extension

• Opportunity to work on cancer dormancy and contribute to the successful translation of a novel glioblastoma drug candidate

• Base Salary $95,047- $105,305+ 17% superannuation

About the opportunity

An exciting post-doctoral position is available in the A/Prof Lenka Munoz’ laboratory to study the mechanism of cancer dormancy and drug tolerance in glioblastoma. Our laboratory has developed and is now translating a new class of cancer drugs into glioblastoma clinical trials. However, glioblastoma tumours contain a small population of drug-tolerant persister cells that evade the effects of drugs by entering a dormant state. To develop therapeutic approaches with full clinical impact, we need to understand the mechanism of dormancy and drug tolerance in glioblastoma. The successful applicant will work on a NHMRC-funded project focused on the delineation of dormancy mechanism and pharmacological exploitation of new targets in drug-tolerant persister cells.

Our laboratory is located in the multi-disciplinary Charles Perkins Centre (CPC) at the main campus of the University of Sydney. CPC provides an outstanding intellectual environment and access to a wide range of cutting-edge technologies in cell imaging, cytometry, genomics and proteomics. The successful applicant will have superb  opportunities to expand their expertise and/or take advantage of the diverse knowledge of the CPC community, and incorporate it into their research project.

Your key responsibilities will be to:

• communicate with key internal and external stakeholders and engage with collaborators at the University of Sydney and nationally

• undertake research using glioblastoma stem cells, molecular biology techniques (incl. CRISPR), live-cell imaging and microscopy, and a variety of pharmacological/phenotypic assays

• demonstrate excellence in data analysis, interpretation of results and directing future experiments

• assist with preparation of manuscripts and competitive research grants

• support the supervision of undergraduate and postgraduate students

• interpret and present data to collaborators, develop profile through presentations at conferences and seminars.

About you

The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Postdoctoral Research Associate who has:

• a PhD in cell/molecular biology or pharmacology or a related discipline (awarded or near completion) 

• background in cancer cell biology and hands-on experience conducting cell-based research, preferably with cancer stem cells

• experience in cell/molecular biology techniques such as CRISPR, RNA interference, PCR, Western blotting and immunofluorescence

• experience with platforms such as Incucyte, Opera Phoenix, flow cytometry to perform phenotypic assays (e.g.; viability, apoptosis, cell cycle, 3D spheroid growth)

• familiarity with sequencing technologies and ability to analyse sequencing and -omics datasets (desirable, but not required)

• recognised contributions to the preparation and analysis of research data, drafting reports and manuscripts

• ability to work effectively within a team and excellent organizational, interpersonal, and communication skills (both verbal and written).

To apply for this position, please address the below statements in a cover letter that you attach to your application:

• outline your experience in performing and/or analyzing sequencing and/or -omics datasets

• outline your current research interests and your plans for your reearch trajectory

• what do you see as being the key current challenge in the identification and validation of novel cancer drug targets

Closing date for applications

11.59pm, Tuesday 16 November 2021

Sponsorship / work rights for Australia

Visa sponsorship is only available for this position for candidates who are currently located within Australia.

Australian Temporary Residents currently employed at the University of Sydney may be considered for a fixed term contract for the length of their visa, depending on the requirements of the hiring area and the position.

Pre-employment checks

Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.

EEO statement

The University of Sydney is committed to diversity and social inclusion. Applications from people of culturally and linguistically diverse backgrounds; equity target groups including women, people with disabilities, people who identify as LGBTIQ; and people of Aboriginal and Torres Strait Islander descent, are encouraged.

How to apply

Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.  

For employees of the University or contingent workers, please login into your Workday account and navigate to the Career icon on your Dashboard.  Click on USYD Find Jobs and apply.

For a confidential discussion about the role, or if you require reasonable adjustment or support filling out this application, please contact Linden Joseph or Rebecca Astar, Recruitment Operations, at [email protected]

© The University of Sydney

The University reserves the right not to proceed with any appointment.

Closing Date: 16 November 2021