Influence of neuromodulators on human spinal motoneurone function and muscle performance

Project Outline:

All human movement occurs through muscle contractions that are controlled by motor nerve cells in the spinal cord. These cells, which are called motoneurones, are primarily controlled by signals from the motor parts of the brain. However, signals from the brainstem are thought to be able to modulate the responses of the spinal motoneurones and enhance their activity. This involves the release of neuromodulators, serotonin and noradrenaline, to affect the motoneurones in the spinal cord. Although these neuromodulators may be critical for human motor performance, when, where and how they are released is poorly understood. Studies in humans will assess aspects of neuromuscular performance to determine whether voluntary contractions or mental stress increase neuromodulator release and enhance motoneurone activity.

Research questions

1. Does voluntary contraction enhance motoneurone activity in muscles that are not contracting?
2. Does mental stress enhance motoneurone activity?
3. Are the effects of voluntary contraction on motoneurone activity in muscles that are not contracting related to release of serotonin?
4. Are the effects of mental stress on motoneurone activity related to the release of noradrenaline?

Desired Skills: This project will suit students with an interest in motor control and neurophysiology. It will require hands-on studies in human participants.

Project Area: Exercise and Sports Science

School / Research Centre / Institute : School of Medical and Health Sciences research

Supervisor(s): Professor Janet Taylor

Project level: Honours, Masters, PhD

Start date: Ongoing