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, the causative agent of leptospirosis, offers an excellent model for studying the mechanisms underlying host adaptation and zoonotic emergence. Virtually all mammalian species can act as reservoirs
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, MP Gantier, LN Casillas, BJ Votta, J Bertin, IG Boneca, C Sasakaw, DJ Philpott, RL Ferrero, M Kaparakis-Liaskos. 2014. NOD1 interacts with peptidoglycan and RIP2 on early endosomes to promote RIP2
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responses induced in antigen presenting cells, and the differentiation of specific B and T cells will be evaluated by spectral flow cytometry and scRNAseq, while CD4+ T cell / B cell interactions will be
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across a range of clinically relevant pathogens. Develop novel computational methods to infer biological function directly from protein sequences, including modeling epistatic interactions and residue
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actively to M1/M2 student co-supervision. Interact and collaborate productively with other researchers within and outside of the team, including bioinformatic engineers. Present data in lab meetings and
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be working on the development of machine learning methods for single-cell data and will require interactions with collaborators of the team. Required skills : We expect a candidate with a strong
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, immune–stromal interactions, and tissue remodeling, including in physiological contexts such as female reproductive biology and aging. Host Lab: Our lab addresses a central question in biology: what is the