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tuberculosis (TB) screening research, spanning the evaluation of novel, high-throughput molecular tests, innovative screening algorithms, and digital health tools. A core component of the role involves
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, the diverse communities of microorganisms that can be either beneficial, or harmful. We combine the powerful genetics of model gut bacteria and Drosophila with multi-omics approaches to understand how symbiosis
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will advance our understanding of real-world pathogen encounters and the establishment and plasticity of innate immune memory. Identified molecular targets will be validated via genetic and
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cultivation protocols for the minimal cell JCVI-Syn3 Establishing maintenance and operating procedures for molecular cloning and genetic manipulation of minimal cells (JCVI-syn3) Assisting in the establishment
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focus on the genetic and epigenetic molecular pathogenesis of pediatric T-cell leukemia (T-ALL). One particular emphasis will be on the multi-omic wet- and dry-lab analysis of clonal and subclonal genomic
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mechanisms. The planned project will use a broad range of technologies, including genetics, imaging, biochemistry, molecular biology, enzymology, cell culture and experimental animal models (mice and zebrafish