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pathways for complex glycan metabolism using a combination of biochemical, genetic, spectroscopic and structural biology approaches Performing bacterial genetic manipulation, protein expression and
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candidate must have expertise in molecular genetics in plant biology. Successful applicants will also have a PhD in plant sciences and a track record of research competency. Good communication and
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research programme with two main strands: (i) bioinformatics experiments to unravel the genetic basis of cardiovascular diseases and discover novel therapeutic targets, including genome-wide association
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research programme with two main strands: (i) bioinformatics experiments to unravel the genetic basis of cardiovascular diseases and discover novel therapeutic targets, including genome-wide association
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to shape infection outcomes. Using the genetically tractable model organism Drosophila melanogaster, this project will determine how infection-induced triglyceride mobilisation influences survival and why
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of DNAAF9 (axonemal dynein assembly factor 9) in ciliary biology. This will involve CRISPR genetic engineering using relevant ciliated cell lines to knockout DNAAF9 followed by cytological, proteomic and
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to shape infection outcomes. Using the genetically tractable model organism Drosophila melanogaster, this project will determine how infection-induced triglyceride mobilisation influences survival and why
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-prone and apoptosis-resistant neurons, and integrate iPSC-derived microglia from defined genetic backgrounds, including APOE3/3 and APOE4/4 lines. The work will combine live imaging, single-cell RNA
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, and use genetic screening approaches to characterise novel nuclear modifiers of disease progression. The focus of your work will be on studying how nuclear and mitochondrial DNA defects lead to tissue
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with Nuffield Department of Clinical Neuroscience (NDCN), Nuffield Department of Population Health (NDPH) and Department of Physiology, Anatomy and Genetics (DPAG). The Institute brings together the very