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Field
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of the pathophysiology of neurodegenerative diseases and to identify novel pathways and targets for the development of therapy. In particular, we are interested in understanding the mechanisms underlying protein
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genetically modified mice, performs stereotaxic brain surgeries to delivery gene therapy through viral vectors or recombinant proteins, analyzes brains using morphological and biochemical assays including
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, cell culture, gene knock-down via siRNA/shRNA). Demonstrated research productivity evidenced by first-author publications in peer-reviewed journals. Preferred Qualifications: Experience in prostate
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signaling, and GPCR or kinase biology is essential. Experience in at least two of the following—mammalian cell culture and iPSC differentiation, site-specific genome integration and CRISPR/Cas9 gene editing
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | about 2 months ago
motivated candidates with a strong record of scientific productivity and innovation. Ideal applicants will have expertise in virology, molecular biology, gene delivery, immune cell therapy, computational
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | about 2 months ago
to study the molecular mechanisms of post-transcriptional gene expression in health and disease. We are an enthusiastic, collaborative team dedicated to tackling outstanding questions at the interface of RNA
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advancing gene therapy research that supports patients and families impacted by neuromuscular disorders. Be Bold. What You’ll Do: • Lead research on respiratory pathology and neuropathology in Duchenne
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understand the pathogenesis of inflammatory bowel disease (IBD) and developing gene editing therapies for IBD. The role will include working with IBD patient-derived organoids, advancing human in vitro assays
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tolerance and treat disease at reduced doses, understanding the mechanisms driving immune tolerance following AAV liver-directed gene therapy, and evaluating the immune responses associated with AAV
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specializes in precision cardiovascular medicine, leveraging cutting-edge approaches such as human iPSC-derived 2D cardiovascular cells, 3D vascularized cardioids, CRISPR gene editing, high-throughput CRISPRko