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mechanisms that determine tumour response to ionising radiation remain incompletely understood. This project aims to identify and characterise genes and pathways that regulate radiation response, with the long
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of neurodevelopmental disorders expertise in preclinical disease modelling, molecular biology, gene editing, viral vector technologies, and translational neuroscience research a strong track record of publications in
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biology, and plant pathology. Learn to perform grapevine tissue culture, genetic transformation, and genome editing techniques. Learn to conduct DNA, RNA, and protein extractions, as well as PCR, qPCR, gene
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USDA-ARS Molecular Biology Postdoctoral Fellowship in the Natural Products Utilization Research Unit
sequence databases, analysis of gene function via CRISPR/Cas-9-mediated genome editing and RNAi, heterologous protein expression, real-time qRT-PCR, and plant transformation using species such as Arabidopsis
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a model system. Current projects integrate high-throughput genomic sequencing, single-cell sequencing, bioinformatic analyses, and CRISPR-Cas gene editing to investigate fundamental questions in
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of Michigan in the Department of Cell & Developmental Biology (CDB). We use a combination of developmental biology models including Xenopus (frog), mouse, and pluripotent stem cells, gene editing, and
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(ESCs, iPSCs), directed differentiation, and advanced cell biology techniques; Be proficient in gene editing (CRISPR-based methods), molecular cloning, and functional assays; Demonstrate strong analytical
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genetic variants, genes and pathways. These mechanisms will be explored further using more complex cell and tissue models combined with spatial transcriptomics of the lung to provide novel understanding
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Experience: Experience in chromatin biology, DNA damage repair, or epigenetics. Experience with techniques such as protein expression/purification, CRISPR/Cas9 gene editing, and advanced microscopy is highly
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to investigate disease-associated genes and signaling pathways. Perform functional immunological experiments investigating immune-cell activation, cytokine responses, antibody-mediated mechanisms, complement