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crack initiation and propagation; Development and validation of a digital twin with an appropriate level of maturity; Proposal and evaluation of new cluster architectures; Validation of optimized
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on which the model is based. The benefits of the proposed methodology will be evaluated through both idealized test cases and realistic simulations, with results compared against available observations
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of the tissue using water-soluble clearing and refractive index matching media, and evaluating the benefits of this approach for three-dimensional imaging. The first year of the project will focus on optimizing
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to investigate how ageing-associated microenvironments affect human adipose tissue physiology. By perfusing the engineered tissues with sera from young and aged donors, the project will evaluate changes in adipose
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the integration of the system with a micro-gas turbine developed by Canadian partners to assess the feasibility of a partially self-powered process; • Contribute to the evaluation of the overall energy efficiency
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response. 4. Functional validation in collaboration with Institut Pasteur Paris. For the most relevant candidate genes, evaluate and compare antiviral activity of mammalian/avian and human orthologs through
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the recommendations made for quality assurance of reference databases (Weigand et al., 2019) and would provide lasting value to the work beyond the thesis itself. (iv) Required Skills Applications will be evaluated
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combination of simulations with different levels of cost and accuracy. • Quantify the uncertainties associated with different levels of accuracy. • Develop criteria for evaluating the contribution of each
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, and the presence of additional Northern Hemisphere ice sheets for the Last Glacial Maximum). Their realism can be evaluated using existing and newly acquired records from the AMACLIM project. Particular